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8og1

From Proteopedia

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Current revision (07:26, 12 July 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8og1 is ON HOLD until Paper Publication
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==Exostosin-like 3 apo enzyme==
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<StructureSection load='8og1' size='340' side='right'caption='[[8og1]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8og1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OG1 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8og1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8og1 OCA], [https://pdbe.org/8og1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8og1 RCSB], [https://www.ebi.ac.uk/pdbsum/8og1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8og1 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/EXTL3_HUMAN EXTL3_HUMAN] Skeletal dysplasia-T-cell immunodeficiency-developmental delay syndrome. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/EXTL3_HUMAN EXTL3_HUMAN] Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs) (PubMed:28132690, PubMed:28148688). Required for the function of REG3A in regulating keratinocyte proliferation and differentiation (PubMed:22727489).<ref>PMID:22727489</ref> <ref>PMID:28132690</ref> <ref>PMID:28148688</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Hohenester E]]
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[[Category: Sammon D]]

Current revision

Exostosin-like 3 apo enzyme

PDB ID 8og1

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