8one
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8one is ON HOLD Authors: Mattoteia, D., De Marco, M., Pinnola, A., Faravelli, S., Scietti, L., Forneris, F. Description: Crystal Structure of full-...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Asp190Ser mutant - Cocrystal with Fe2+, Mn2+, UDP-Glucose== | |
| - | + | <StructureSection load='8one' size='340' side='right'caption='[[8one]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8one]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ONE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ONE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |
| - | [[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UPG:URIDINE-5-DIPHOSPHATE-GLUCOSE'>UPG</scene></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8one FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8one OCA], [https://pdbe.org/8one PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8one RCSB], [https://www.ebi.ac.uk/pdbsum/8one PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8one ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: De Marco | + | [https://www.uniprot.org/uniprot/PLOD3_HUMAN PLOD3_HUMAN] Connective tissue disorder due to lysyl hydroxylase-3 deficiency. The disease is caused by mutations affecting the gene represented in this entry. |
| - | [[Category: Faravelli | + | == Function == |
| - | [[Category: Mattoteia | + | [https://www.uniprot.org/uniprot/PLOD3_HUMAN PLOD3_HUMAN] Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.[UniProtKB:P24802] |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: De Marco M]] | ||
| + | [[Category: Faravelli S]] | ||
| + | [[Category: Forneris F]] | ||
| + | [[Category: Mattoteia D]] | ||
| + | [[Category: Pinnola A]] | ||
| + | [[Category: Scietti L]] | ||
Current revision
Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Asp190Ser mutant - Cocrystal with Fe2+, Mn2+, UDP-Glucose
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