8gv8

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Current revision (14:37, 6 November 2024) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[8gv8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GV8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[8gv8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GV8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4KU:2,2-ETHANE-1,2-DIYLBIS{5-[(SULFANYLMETHYL)AMINO]BENZENESULFONIC+ACID}'>4KU</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.08&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4KU:2,2-ETHANE-1,2-DIYLBIS{5-[(SULFANYLMETHYL)AMINO]BENZENESULFONIC+ACID}'>4KU</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gv8 OCA], [https://pdbe.org/8gv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gv8 RCSB], [https://www.ebi.ac.uk/pdbsum/8gv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gv8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gv8 OCA], [https://pdbe.org/8gv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gv8 RCSB], [https://www.ebi.ac.uk/pdbsum/8gv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gv8 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/B3A2_HUMAN B3A2_HUMAN] The disease may be caused by variants affecting the gene represented in this entry.
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/B3A2_HUMAN B3A2_HUMAN] Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity).[UniProtKB:P13808]<ref>PMID:15184086</ref> <ref>PMID:34668226</ref>
[https://www.uniprot.org/uniprot/B3A2_HUMAN B3A2_HUMAN] Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity).[UniProtKB:P13808]<ref>PMID:15184086</ref> <ref>PMID:34668226</ref>
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</div>
</div>
<div class="pdbe-citations 8gv8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 8gv8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Anion exchange protein 3D structures|Anion exchange protein 3D structures]]
== References ==
== References ==
<references/>
<references/>

Current revision

The cryo-EM structure of hAE2 with DIDS

PDB ID 8gv8

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