1joc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /> <applet load="1joc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1joc, resolution 2.2&Aring;" /> '''EEA1 homodimer of C-...)
Current revision (07:41, 7 February 2024) (edit) (undo)
 
(19 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1joc.gif|left|200px]]<br />
 
-
<applet load="1joc" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1joc, resolution 2.2&Aring;" />
 
-
'''EEA1 homodimer of C-terminal FYVE domain bound to inositol 1,3-diphosphate'''<br />
 
-
==Overview==
+
==EEA1 homodimer of C-terminal FYVE domain bound to inositol 1,3-diphosphate==
-
Early endosome autoantigen localization to early endosomes is mediated by, a C-terminal region, which includes a calmodulin binding motif, a Rab5, interaction site, and a FYVE domain that selectively binds phosphatidyl, inositol 3-phosphate. The crystal structure of the C-terminal region bound, to inositol 1,3-bisphosphate reveals an organized, quaternary assembly, consisting of a parallel coiled coil and a dyad-symmetric FYVE domain, homodimer. Structural and biochemical observations support a multivalent, mechanism for endosomal localization in which domain organization, dimerization, and quaternary structure amplify the weak affinity and, modest specificity of head group interactions with conserved residues. A, unique mode of membrane engagement deduced from the quaternary structure, of the C-terminal region provides insight into the structural basis of, endosome tethering.
+
<StructureSection load='1joc' size='340' side='right'caption='[[1joc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==Disease==
+
<table><tr><td colspan='2'>[[1joc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The March 2007 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Zinc Fingers'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2007_3 10.2210/rcsb_pdb/mom_2007_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JOC FirstGlance]. <br>
-
Known disease associated with this structure: Spastic paraplegia 33 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=610243 610243]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ITP:PHOSPHORIC+ACID+MONO-(2,3,4,6-TETRAHYDROXY-5-PHOSPHONOOXY-CYCLOHEXYL)+ESTER'>ITP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1joc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1joc OCA], [https://pdbe.org/1joc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1joc RCSB], [https://www.ebi.ac.uk/pdbsum/1joc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1joc ProSAT]</span></td></tr>
-
1JOC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN and ITP as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1JOC with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_1.html Zinc Fingers]]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JOC OCA].
+
</table>
-
 
+
== Function ==
-
==Reference==
+
[https://www.uniprot.org/uniprot/EEA1_HUMAN EEA1_HUMAN] Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
-
Multivalent endosome targeting by homodimeric EEA1., Dumas JJ, Merithew E, Sudharshan E, Rajamani D, Hayes S, Lawe D, Corvera S, Lambright DG, Mol Cell. 2001 Nov;8(5):947-58. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11741531 11741531]
+
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jo/1joc_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1joc ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
 +
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Zinc Fingers]]
[[Category: Zinc Fingers]]
-
[[Category: Corvera, S.]]
+
[[Category: Corvera S]]
-
[[Category: Dumas, J.J.]]
+
[[Category: Dumas JJ]]
-
[[Category: Hayes, S.]]
+
[[Category: Hayes S]]
-
[[Category: Lambright, D.G.]]
+
[[Category: Lambright DG]]
-
[[Category: Lawe, D.]]
+
[[Category: Lawe D]]
-
[[Category: Merithew, E.]]
+
[[Category: Merithew E]]
-
[[Category: Rajamani, D.]]
+
[[Category: Rajamani D]]
-
[[Category: ITP]]
+
-
[[Category: ZN]]
+
-
[[Category: fyve domain]]
+
-
[[Category: inositol 3-phosphate binding]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:43:00 2007''
+

Current revision

EEA1 homodimer of C-terminal FYVE domain bound to inositol 1,3-diphosphate

PDB ID 1joc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1joc"
Personal tools