Efavirenz/emtricitabine/tenofovir
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| - | <StructureSection load='' size='340' side='right' caption=' | + | <StructureSection load='' size='340' side='right' caption='Efavirenz/emtricitabinne/tenofovir' scene='96/960003/Cv/1'> |
Efavirenz/emtricitabine/tenofovir, sold under the brand name Atripla among others, is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS. It contains [[efavirenz]], [[emtricitabine]], and [[Tenofovir|tenofovir disoproxil]]. It can be used by itself or together with other antiretroviral medications. Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) of HIV-1. Tenofovir is a nucleotide reverse transcriptase inhibitor of HIV-1, and it can be classified as an NtRTI. These three drugs work in combination to target the HIV reverse transcriptase protein in three ways, which reduces the virus's capacity to mutate. | Efavirenz/emtricitabine/tenofovir, sold under the brand name Atripla among others, is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS. It contains [[efavirenz]], [[emtricitabine]], and [[Tenofovir|tenofovir disoproxil]]. It can be used by itself or together with other antiretroviral medications. Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) of HIV-1. Tenofovir is a nucleotide reverse transcriptase inhibitor of HIV-1, and it can be classified as an NtRTI. These three drugs work in combination to target the HIV reverse transcriptase protein in three ways, which reduces the virus's capacity to mutate. | ||
| + | <scene name='95/958584/Cv/3'>Structure of HIV-1 reverse transcriptase initiation complex core with efavirenz</scene> ([[7kjw]]). | ||
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| + | <scene name='95/958584/Cv/4'>Efavirenz binding site</scene>. | ||
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| + | <scene name='95/959998/Cv/4'>Emtricitabine binding site</scene> at reverse transcriptase ([[2no6]]). Water molecules are shown as red spheres. | ||
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| + | <scene name='96/960003/Cv/3'>Tenofovir diphosphate (TNV) binding site</scene> at reverse transcriptase ([[3fkb]]). Water molecules are shown as red spheres. | ||
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| + | <scene name='96/960003/Tnmbindingsite/5'>Tenofovir-monophosphate (TNM) binding site</scene> at reverse transcriptase ([[3fkb]]). | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
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