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8iz7
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==cryo-EM structure of sulindac-bound hMRP4== | |
| - | + | <StructureSection load='8iz7' size='340' side='right'caption='[[8iz7]], [[Resolution|resolution]] 3.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8iz7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IZ7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SUZ:[(1Z)-5-FLUORO-2-METHYL-1-{4-[METHYLSULFINYL]BENZYLIDENE}-1H-INDEN-3-YL]ACETIC+ACID'>SUZ</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8iz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8iz7 OCA], [https://pdbe.org/8iz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8iz7 RCSB], [https://www.ebi.ac.uk/pdbsum/8iz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8iz7 ProSAT]</span></td></tr> |
| - | [[Category: Huang | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MRP4_HUMAN MRP4_HUMAN] ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685).<ref>PMID:11106685</ref> <ref>PMID:11856762</ref> <ref>PMID:12105214</ref> <ref>PMID:12523936</ref> <ref>PMID:12835412</ref> <ref>PMID:12883481</ref> <ref>PMID:15364914</ref> <ref>PMID:15454390</ref> <ref>PMID:16282361</ref> <ref>PMID:17344354</ref> <ref>PMID:17959747</ref> <ref>PMID:18300232</ref> <ref>PMID:26721430</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Huang Y]] | ||
| + | [[Category: Liu ZM]] | ||
Current revision
cryo-EM structure of sulindac-bound hMRP4
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