7zw6

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Current revision (11:51, 23 October 2024) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7zw6]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechocystis_sp._PCC_6803 Synechocystis sp. PCC 6803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZW6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[7zw6]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechocystis_sp._PCC_6803 Synechocystis sp. PCC 6803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZW6 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zw6 OCA], [https://pdbe.org/7zw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zw6 RCSB], [https://www.ebi.ac.uk/pdbsum/7zw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zw6 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zw6 OCA], [https://pdbe.org/7zw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zw6 RCSB], [https://www.ebi.ac.uk/pdbsum/7zw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zw6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/P73765_SYNY3 P73765_SYNY3]
[https://www.uniprot.org/uniprot/P73765_SYNY3 P73765_SYNY3]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Dynamin-like proteins are membrane remodeling GTPases with well-understood functions in eukaryotic cells. However, bacterial dynamin-like proteins are still poorly investigated. SynDLP, the dynamin-like protein of the cyanobacterium Synechocystis sp. PCC 6803, forms ordered oligomers in solution. The 3.7 A resolution cryo-EM structure of SynDLP oligomers reveals the presence of oligomeric stalk interfaces typical for eukaryotic dynamin-like proteins. The bundle signaling element domain shows distinct features, such as an intramolecular disulfide bridge that affects the GTPase activity, or an expanded intermolecular interface with the GTPase domain. In addition to typical GD-GD contacts, such atypical GTPase domain interfaces might be a GTPase activity regulating tool in oligomerized SynDLP. Furthermore, we show that SynDLP interacts with and intercalates into membranes containing negatively charged thylakoid membrane lipids independent of nucleotides. The structural characteristics of SynDLP oligomers suggest it to be the closest known bacterial ancestor of eukaryotic dynamin.
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SynDLP is a dynamin-like protein of Synechocystis sp. PCC 6803 with eukaryotic features.,Gewehr L, Junglas B, Jilly R, Franz J, Zhu WE, Weidner T, Bonn M, Sachse C, Schneider D Nat Commun. 2023 Apr 14;14(1):2156. doi: 10.1038/s41467-023-37746-9. PMID:37059718<ref>PMID:37059718</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7zw6" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>

Current revision

Oligomeric structure of SynDLP

PDB ID 7zw6

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