8dh8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:22, 12 June 2024) (edit) (undo)
 
Line 4: Line 4:
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[8dh8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DH8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[8dh8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DH8 FirstGlance]. <br>
-
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dh8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dh8 OCA], [https://pdbe.org/8dh8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dh8 RCSB], [https://www.ebi.ac.uk/pdbsum/8dh8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dh8 ProSAT]</span></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.9&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dh8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dh8 OCA], [https://pdbe.org/8dh8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dh8 RCSB], [https://www.ebi.ac.uk/pdbsum/8dh8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dh8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[https://www.uniprot.org/uniprot/LEPR_MOUSE LEPR_MOUSE] Receptor for hormone LEP/leptin (Probable) (PubMed:11861497). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS (PubMed:10799542, PubMed:25383904, PubMed:11923481, PubMed:11861497). In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (PubMed:10660043, PubMed:12594516). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25383904, PubMed:11923481). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis (PubMed:12594516). Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus (PubMed:25383904). Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (PubMed:9732873).<ref>PMID:10660043</ref> <ref>PMID:10799542</ref> <ref>PMID:11861497</ref> <ref>PMID:11923481</ref> <ref>PMID:12594516</ref> <ref>PMID:25383904</ref> <ref>PMID:9732873</ref> <ref>PMID:25232147</ref> May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis (PubMed:17620316, PubMed:20223942). Does not induce phosphorylation of and activate STAT3 (PubMed:11923481, PubMed:20223942).<ref>PMID:11923481</ref> <ref>PMID:17620316</ref> <ref>PMID:20223942</ref> Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis.<ref>PMID:17620316</ref>
+
[https://www.uniprot.org/uniprot/LEPR_MOUSE LEPR_MOUSE] Receptor for hormone LEP/leptin (Probable) (PubMed:11861497). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS (PubMed:10799542, PubMed:11861497, PubMed:11923481, PubMed:25383904). In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (PubMed:10660043, PubMed:12594516). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:11923481, PubMed:25383904). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis (PubMed:12594516). Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus (PubMed:25383904). Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (PubMed:9732873).<ref>PMID:10660043</ref> <ref>PMID:10799542</ref> <ref>PMID:11861497</ref> <ref>PMID:11923481</ref> <ref>PMID:12594516</ref> <ref>PMID:25383904</ref> <ref>PMID:9732873</ref> <ref>PMID:25232147</ref> May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis (PubMed:17620316, PubMed:20223942). Does not induce phosphorylation of and activate STAT3 (PubMed:11923481, PubMed:20223942).<ref>PMID:11923481</ref> <ref>PMID:17620316</ref> <ref>PMID:20223942</ref> Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis.<ref>PMID:17620316</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Current revision

Leptin-bound leptin receptor complex-full ECD

PDB ID 8dh8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8dh8"
Personal tools