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8j0l

From Proteopedia

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Current revision (05:47, 5 July 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8j0l is ON HOLD until Paper Publication
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==Structure of DNA binding Domain of Human TFAP2A==
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<StructureSection load='8j0l' size='340' side='right'caption='[[8j0l]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
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Authors: Liu, K., Xiao, Y.Q., Gan, L.Y., Min, J.R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8j0l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J0L FirstGlance]. <br>
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Description: Structure of DNA binding Domain of Human TFAP2A
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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[[Category: Xiao, Y.Q]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j0l OCA], [https://pdbe.org/8j0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j0l RCSB], [https://www.ebi.ac.uk/pdbsum/8j0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j0l ProSAT]</span></td></tr>
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[[Category: Gan, L.Y]]
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</table>
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[[Category: Min, J.R]]
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== Disease ==
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[[Category: Liu, K]]
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[https://www.uniprot.org/uniprot/AP2A_HUMAN AP2A_HUMAN] Branchio-oculo-facial syndrome. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/AP2A_HUMAN AP2A_HUMAN] Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.<ref>PMID:11694877</ref> <ref>PMID:12586840</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Gan LY]]
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[[Category: Liu K]]
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[[Category: Min JR]]
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[[Category: Xiao YQ]]

Current revision

Structure of DNA binding Domain of Human TFAP2A

PDB ID 8j0l

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OCA

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