8j19
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the LY237-bound GPR84 receptor-Gi complex== | |
| - | + | <StructureSection load='8j19' size='340' side='right'caption='[[8j19]], [[Resolution|resolution]] 3.23Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8j19]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J19 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.23Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SWO:6-nonylpyridine-2,4-diol'>SWO</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j19 OCA], [https://pdbe.org/8j19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j19 RCSB], [https://www.ebi.ac.uk/pdbsum/8j19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j19 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Liu | + | == Function == |
| + | [https://www.uniprot.org/uniprot/GPR84_HUMAN GPR84_HUMAN] Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system.<ref>PMID:16966319</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Liu H]] | ||
| + | [[Category: Xu HE]] | ||
| + | [[Category: Yin W]] | ||
Current revision
Cryo-EM structure of the LY237-bound GPR84 receptor-Gi complex
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