8sim

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(New page: '''Unreleased structure''' The entry 8sim is ON HOLD Authors: Description: Category: Unreleased Structures)
Current revision (06:58, 19 June 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8sim is ON HOLD
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==KCNQ1 with voltage sensor in the intermediate conformation==
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<StructureSection load='8sim' size='340' side='right'caption='[[8sim]], [[Resolution|resolution]] 6.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8sim]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SIM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sim OCA], [https://pdbe.org/8sim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sim RCSB], [https://www.ebi.ac.uk/pdbsum/8sim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sim ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
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== Function ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
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Authors:
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==See Also==
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: MacKinnon R]]
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[[Category: Mandala VS]]

Current revision

KCNQ1 with voltage sensor in the intermediate conformation

PDB ID 8sim

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