Haloperoxidase

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== Function ==
== Function ==
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'''Haloperoxidases''' catalyze the oxidation of halides by hydrogen peroxide while adding a halide to hydrocarbons. They are classified as '''chloroperoxldase''' (CPO), '''bromoperoxidase''' (BPO) and '''iodoperoxidase''' (IPO) according to the halide which they oxidize. CPO is heme-containing, vanadium-containing or metal-free. BPO from marine algae is vanadium-containing<ref>PMID:19363038</ref>.
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'''Haloperoxidases''' catalyze the oxidation of halides by hydrogen peroxide while adding a halide to hydrocarbons. They are classified as '''chloroperoxldase''' (CPO), '''bromoperoxidase''' (BPO) and '''iodoperoxidase''' (IPO) according to the halide which they oxidize.
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*'''CPO''' is heme-containing, vanadium-containing or metal-free.
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*'''BPO''' is from marine algae is vanadium-containing<ref>PMID:19363038</ref>.
== Structural highlights ==
== Structural highlights ==
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**[[3w35]] – StCPO – ''Streptomyces''<br />
**[[3w35]] – StCPO – ''Streptomyces''<br />
**[[3w36]] – StCPO + VO4<br />
**[[3w36]] – StCPO + VO4<br />
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**[[5lpc]] – CPO – ''Acaryochloris marina''<br />
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**[[5lpc]] – AmCPO – ''Acaryochloris marina''<br />
*Heme-containing chloroperoxidase
*Heme-containing chloroperoxidase
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**[[5aa6]] – AnBPO-2 + VO4<br />
**[[5aa6]] – AnBPO-2 + VO4<br />
**[[1up8]], [[1qhb]], [[7qyy]] – CpBPO – ''Corallina pilulifera''<br />
**[[1up8]], [[1qhb]], [[7qyy]] – CpBPO – ''Corallina pilulifera''<br />
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**[[8vgx]] – CpBPO – Cryo EM<br />
**[[7qvw]] – CpBPO (mutant) <br />
**[[7qvw]] – CpBPO (mutant) <br />
**[[7qwi]] – CpBPO + VO4<br />
**[[7qwi]] – CpBPO + VO4<br />
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**[[8vh0]] – CpBPO + VO4 – Cryo EM<br />
**[[7qw3]] – CpBPO (mutant) + Br<br />
**[[7qw3]] – CpBPO (mutant) + Br<br />
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**[[8vjq]] – CpBPO + VO4 + Br – Cryo EM<br />
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**[[8vix]] – CpBPO + VO4 + O2 – Cryo EM<br />
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**[[8q20]], [[8q21]], [[8q22]] – AmBPO (mutant)<br />
*Vanadium-containing iodoperoxidase
*Vanadium-containing iodoperoxidase

Current revision

Bromoperoxidase complex with VO4 and I- (purple) ions, 1qi9

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3D structures of haloperoxidase

Updated on 07-August-2025

References

  1. Winter JM, Moore BS. Exploring the chemistry and biology of vanadium-dependent haloperoxidases. J Biol Chem. 2009 Jul 10;284(28):18577-81. doi: 10.1074/jbc.R109.001602. Epub, 2009 Apr 10. PMID:19363038 doi:http://dx.doi.org/10.1074/jbc.R109.001602
  2. Weyand M, Hecht H, Kiess M, Liaud M, Vilter H, Schomburg D. X-ray structure determination of a vanadium-dependent haloperoxidase from Ascophyllum nodosum at 2.0 A resolution. J Mol Biol. 1999 Oct 29;293(3):595-611. PMID:10543953 doi:10.1006/jmbi.1999.3179

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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