7fz2

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m (Protected "7fz2" [edit=sysop:move=sysop])
Current revision (06:20, 21 November 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7fz2 is ON HOLD
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==Crystal Structure of human FABP4 in complex with [3-oxo-5-[4-(trifluoromethyl)phenyl]cyclohexen-1-yl] acetate, i.e. SMILES [C@H]1(c2ccc(cc2)C(F)(F)F)CC(=CC(=O)C1)OC(=O)C with IC50=0.833 microM==
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<StructureSection load='7fz2' size='340' side='right'caption='[[7fz2]], [[Resolution|resolution]] 1.12&Aring;' scene=''>
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Authors: Ehler, A., Benz, J., Obst, U., Kumagai, Y., Rudolph, M.G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7fz2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FZ2 FirstGlance]. <br>
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Description: Crystal Structure of human FABP4 in complex with [3-oxo-5-[4-(trifluoromethyl)phenyl]cyclohexen-1-yl] acetate
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.12&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=WDI:(5~{S})-3-oxidanyl-5-[4-(trifluoromethyl)phenyl]cyclohex-2-en-1-one'>WDI</scene></td></tr>
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[[Category: Ehler, A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fz2 OCA], [https://pdbe.org/7fz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fz2 RCSB], [https://www.ebi.ac.uk/pdbsum/7fz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fz2 ProSAT]</span></td></tr>
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[[Category: Benz, J]]
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</table>
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[[Category: Kumagai, Y]]
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== Function ==
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[[Category: Obst, U]]
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[https://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
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[[Category: Rudolph, M.G]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Benz J]]
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[[Category: Ehler A]]
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[[Category: Kumagai Y]]
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[[Category: Obst U]]
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[[Category: Rudolph MG]]

Current revision

Crystal Structure of human FABP4 in complex with [3-oxo-5-[4-(trifluoromethyl)phenyl]cyclohexen-1-yl] acetate, i.e. SMILES [C@H]1(c2ccc(cc2)C(F)(F)F)CC(=CC(=O)C1)OC(=O)C with IC50=0.833 microM

PDB ID 7fz2

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OCA

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