7g1f

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(New page: '''Unreleased structure''' The entry 7g1f is ON HOLD Authors: Ehler, A., Benz, J., Obst, U., Stempel, A., Rudolph, M.G. Description: Crystal Structure of human FABP4 in complex with 1-...)
Current revision (08:40, 13 August 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7g1f is ON HOLD
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==Crystal Structure of human FABP4 in complex with 1-(4-methylphenyl)sulfonyl-3-(8-tricyclo[5.2.1.02,6]decanyl)urea, i.e. SMILES [C@@H]12[C@H]3[C@@H]([C@H](C2)C[C@H]1NC(=O)NS(=O)(=O)c1ccc(cc1)C)CCC3 with IC50=1.3 microM==
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<StructureSection load='7g1f' size='340' side='right'caption='[[7g1f]], [[Resolution|resolution]] 0.91&Aring;' scene=''>
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Authors: Ehler, A., Benz, J., Obst, U., Stempel, A., Rudolph, M.G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7g1f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7G1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7G1F FirstGlance]. <br>
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Description: Crystal Structure of human FABP4 in complex with 1-(4-methylphenyl)sulfonyl-3-(8-tricyclo[5.2.1.02,6]decanyl)urea
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.91&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=WNW:1-(4-methylphenyl)sulfonyl-3-[(1~{R},2~{R},6~{R},7~{R},8~{R})-8-tricyclo[5.2.1.0^{2,6}]decanyl]urea'>WNW</scene></td></tr>
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[[Category: Ehler, A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7g1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7g1f OCA], [https://pdbe.org/7g1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7g1f RCSB], [https://www.ebi.ac.uk/pdbsum/7g1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7g1f ProSAT]</span></td></tr>
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[[Category: Benz, J]]
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</table>
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[[Category: Stempel, A]]
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== Function ==
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[[Category: Obst, U]]
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[https://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
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[[Category: Rudolph, M.G]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Benz J]]
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[[Category: Ehler A]]
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[[Category: Obst U]]
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[[Category: Rudolph MG]]
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[[Category: Stempel A]]

Current revision

Crystal Structure of human FABP4 in complex with 1-(4-methylphenyl)sulfonyl-3-(8-tricyclo[5.2.1.02,6]decanyl)urea, i.e. SMILES [C@@H]12[C@H]3[C@@H]([C@H](C2)C[C@H]1NC(=O)NS(=O)(=O)c1ccc(cc1)C)CCC3 with IC50=1.3 microM

PDB ID 7g1f

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