7g1g
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7g1g is ON HOLD Authors: Ehler, A., Benz, J., Obst, U., Hochstetler-A., D., Rudolph, M.G. Description: Crystal Structure of human FABP4 in complex ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of human FABP4 in complex with 2-(2-hydroxy-3,5,5,8,8-pentamethyl-3,4,4a,6,7,8a-hexahydro-1H-naphthalen-2-yl)acetic acid, i.e. SMILES [C@H]12[C@@H](C(CCC1(C)C)(C)C)C[C@@H]([C@](C2)(CC(=O)O)O)C with IC50=0.315 microM== | |
| - | + | <StructureSection load='7g1g' size='340' side='right'caption='[[7g1g]], [[Resolution|resolution]] 1.03Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7g1g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7G1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7G1G FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.03Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=WO0:[(2S,3S,4aR,8aR)-2-hydroxy-3,5,5,8,8-pentamethyldecahydronaphthalen-2-yl]acetic+acid'>WO0</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7g1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7g1g OCA], [https://pdbe.org/7g1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7g1g RCSB], [https://www.ebi.ac.uk/pdbsum/7g1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7g1g ProSAT]</span></td></tr> |
| - | [[Category: Benz | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Hochstetler-A]] | + | [https://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). |
| - | [[Category: Obst | + | __TOC__ |
| - | [[Category: Rudolph | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Benz J]] | ||
| + | [[Category: Ehler A]] | ||
| + | [[Category: Hochstetler-A D]] | ||
| + | [[Category: Obst U]] | ||
| + | [[Category: Rudolph MG]] | ||
Current revision
Crystal Structure of human FABP4 in complex with 2-(2-hydroxy-3,5,5,8,8-pentamethyl-3,4,4a,6,7,8a-hexahydro-1H-naphthalen-2-yl)acetic acid, i.e. SMILES [C@H]12[C@@H](C(CCC1(C)C)(C)C)C[C@@H]([C@](C2)(CC(=O)O)O)C with IC50=0.315 microM
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