7g1m

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 7g1m is ON HOLD Authors: Ehler, A., Benz, J., Obst, U., Neidhart, W., Rudolph, M.G. Description: Crystal Structure of human FABP4 binding site muta...)
Current revision (08:40, 13 August 2025) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 7g1m is ON HOLD
+
==Crystal Structure of human FABP4 binding site mutated to that of FABP5 in complex with rac-(1R,2R)-2-[[3-(3-methyl-1,2,4-oxadiazol-5-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]carbamoyl]cyclohexane-1-carboxylic acid, i.e. SMILES C1(=C(C2=C(S1)CCCC2)C1=NC(=NO1)C)NC(=O)[C@@H]1[C@H](CCCC1)C(=O)O with IC50=0.365 microM==
-
 
+
<StructureSection load='7g1m' size='340' side='right'caption='[[7g1m]], [[Resolution|resolution]] 1.34&Aring;' scene=''>
-
Authors: Ehler, A., Benz, J., Obst, U., Neidhart, W., Rudolph, M.G.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[7g1m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7G1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7G1M FirstGlance]. <br>
-
Description: Crystal Structure of human FABP4 binding site mutated to that of FABP5 in complex with rac-(1R,2R)-2-[[3-(3-methyl-1,2,4-oxadiazol-5-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]carbamoyl]cyclohexane-1-carboxylic acid
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.34&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WOU:(1~{R},2~{S})-2-[[3-(3-methyl-1,2,4-oxadiazol-5-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]carbamoyl]cyclohexane-1-carboxylic+acid'>WOU</scene></td></tr>
-
[[Category: Neidhart, W]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7g1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7g1m OCA], [https://pdbe.org/7g1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7g1m RCSB], [https://www.ebi.ac.uk/pdbsum/7g1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7g1m ProSAT]</span></td></tr>
-
[[Category: Ehler, A]]
+
</table>
-
[[Category: Benz, J]]
+
== Function ==
-
[[Category: Obst, U]]
+
[https://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
-
[[Category: Rudolph, M.G]]
+
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Benz J]]
 +
[[Category: Ehler A]]
 +
[[Category: Neidhart W]]
 +
[[Category: Obst U]]
 +
[[Category: Rudolph MG]]

Current revision

Crystal Structure of human FABP4 binding site mutated to that of FABP5 in complex with rac-(1R,2R)-2-[[3-(3-methyl-1,2,4-oxadiazol-5-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]carbamoyl]cyclohexane-1-carboxylic acid, i.e. SMILES C1(=C(C2=C(S1)CCCC2)C1=NC(=NO1)C)NC(=O)[C@@H]1[C@H](CCCC1)C(=O)O with IC50=0.365 microM

PDB ID 7g1m

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7g1m"
Personal tools