8j72

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(New page: '''Unreleased structure''' The entry 8j72 is ON HOLD Authors: Shi, F.D., Zhang, K., Che, S.Y., Zhi, S.X., Yang, N. Description: Crystal structure of mammalian Trim71 in complex with ln...)
Current revision (12:06, 6 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8j72 is ON HOLD
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==Crystal structure of mammalian Trim71 in complex with lncRNA Trincr1==
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<StructureSection load='8j72' size='340' side='right'caption='[[8j72]], [[Resolution|resolution]] 3.16&Aring;' scene=''>
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Authors: Shi, F.D., Zhang, K., Che, S.Y., Zhi, S.X., Yang, N.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8j72]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J72 FirstGlance]. <br>
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Description: Crystal structure of mammalian Trim71 in complex with lncRNA Trincr1
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.16&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j72 OCA], [https://pdbe.org/8j72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j72 RCSB], [https://www.ebi.ac.uk/pdbsum/8j72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j72 ProSAT]</span></td></tr>
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[[Category: Yang, N]]
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</table>
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[[Category: Zhi, S.X]]
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== Function ==
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[[Category: Shi, F.D]]
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[https://www.uniprot.org/uniprot/LIN41_MOUSE LIN41_MOUSE] E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (PubMed:19898466). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression (PubMed:22735451). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (PubMed:22735451). Specific regulator of miRNA biogenesis. miRNA Binds MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (By similarity).[UniProtKB:Q2Q1W2]<ref>PMID:19898466</ref> <ref>PMID:22735451</ref> <ref>PMID:23125361</ref>
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[[Category: Che, S.Y]]
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== References ==
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[[Category: Zhang, K]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Che SY]]
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[[Category: Shi FD]]
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[[Category: Yang N]]
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[[Category: Zhang K]]
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[[Category: Zhi SX]]

Current revision

Crystal structure of mammalian Trim71 in complex with lncRNA Trincr1

PDB ID 8j72

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