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Helicase 3D structures

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Current revision (08:42, 10 May 2023) (edit) (undo)
 
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Line 207: Line 207:
**[[5e7m]], [[5e7j]] – hDDX3X catalytic domain + nucleotide<br />
**[[5e7m]], [[5e7j]] – hDDX3X catalytic domain + nucleotide<br />
**[[3fe2]] – hDDX5 + ADP<br />
**[[3fe2]] – hDDX5 + ADP<br />
-
2wax, 2way, [[6f9s]] – hDDX6 C terminal + peptide
+
**[[2wax]], [[2way]], [[6f9s]] – hDDX6 C terminal + peptide<br />
**[[2pl3]] – hDDX10 DEAD domain + ADP<br />
**[[2pl3]] – hDDX10 DEAD domain + ADP<br />
**[[6uv1]], [[6uv2]], [[6uv3]], [[6uv4]] – hDDX17 core domain + RNA<br />
**[[6uv1]], [[6uv2]], [[6uv3]], [[6uv4]] – hDDX17 core domain + RNA<br />
- 
**[[6b4k]] – hDDX19B residues 54-479 + ANP<br />
**[[6b4k]] – hDDX19B residues 54-479 + ANP<br />
**[[6b4j]], [[6b4i]] – hDDX19B residues 54-479 + GLE1 + Nup42 + ANP<br />
**[[6b4j]], [[6b4i]] – hDDX19B residues 54-479 + GLE1 + Nup42 + ANP<br />
Line 265: Line 264:
**[[6hyt]] – hDHX8 helicase domain + ADP<br />
**[[6hyt]] – hDHX8 helicase domain + ADP<br />
**[[6hyu]] – hDHX8 helicase domain + RNA<br />
**[[6hyu]] – hDHX8 helicase domain + RNA<br />
 +
**[[5mqf]], [[7w59]] – hDHX8 in pre-C*-I complex – Cryo EM<br />
**[[3llm]] – hDHX9<br />
**[[3llm]] – hDHX9<br />
**[[5xdr]] – hDHX15 residues 110-795 (mutant)<br />
**[[5xdr]] – hDHX15 residues 110-795 (mutant)<br />
 +
**[[8ejm]] – hDHX15 residues 110-795 + SUGP1<br />
**[[6sh6]], [[6sh7]] – hDHX15 + Nfkb-repressing factor + ADP<br />
**[[6sh6]], [[6sh7]] – hDHX15 + Nfkb-repressing factor + ADP<br />
 +
**[[5z58]] – hDHX16 in spliceosome – Cryo EM<br />
**[[2n16]] – hDHX36 G-quadruplex domain - NMR<br />
**[[2n16]] – hDHX36 G-quadruplex domain - NMR<br />
 +
**[[7a5p]] – hDHX38 in spliceosome – Cryo EM<br />
**[[2rqa]] – hDHX58 C terminal – NMR<br />
**[[2rqa]] – hDHX58 C terminal – NMR<br />
**[[3vyx]], [[3vyy]] – hDHX9 RNA-binding domain + RNA<br />
**[[3vyx]], [[3vyy]] – hDHX9 RNA-binding domain + RNA<br />
Line 275: Line 278:
**[[5e3h]] - hDHX58 residues 232-925 + RNA<br />
**[[5e3h]] - hDHX58 residues 232-925 + RNA<br />
**[[3eqt]]- hDHX58 residues 541-678 + RNA<br />
**[[3eqt]]- hDHX58 residues 541-678 + RNA<br />
-
**[[5vha]] – bDHX36 residues 150-1010 - bovine<br />
+
**[[5vha]] – bDHX36 residues 150-1010 <br />
**[[5vhc]], [[5vhd]] – bDHX36 residues 150-1010 + ADP<br />
**[[5vhc]], [[5vhd]] – bDHX36 residues 150-1010 + ADP<br />
**[[5vhe]] – bDHX36 residues 56-1010 + DNA<br />
**[[5vhe]] – bDHX36 residues 56-1010 + DNA<br />
**[[2rs6]], [[2rs7]] – mDHX9 RNA-binding domain – NMR<br />
**[[2rs6]], [[2rs7]] – mDHX9 RNA-binding domain – NMR<br />
 +
**[[6up2]] – mDHX36 <br />
**[[6up4]] – mDHX36 + ADP <br />
**[[6up4]] – mDHX36 + ADP <br />
 +
**[[6up3]] – mDHX36 + ANP <br />
 +
**[[5n6e]], [[5n8r]], [[5n8s]], [[5n8u]], [[5n8z]], [[5n90]], [[5n94]], [[5n98]], [[5n9a]], [[5n9f]] – DmDHX36 + DNA <br />
**[[7dcq]] – yPrp2 – Cryo EM<br />
**[[7dcq]] – yPrp2 – Cryo EM<br />
**[[7dcr]] – yPrp2 + Spp2 – Cryo EM<br />
**[[7dcr]] – yPrp2 + Spp2 – Cryo EM<br />
**[[7dd3]] – yPrp2 + Spp2 + RNA – Cryo EM<br />
**[[7dd3]] – yPrp2 + Spp2 + RNA – Cryo EM<br />
**[[7dcp]] – yPrp2 + Spp2 + ADP – Cryo EM<br />
**[[7dcp]] – yPrp2 + Spp2 + ADP – Cryo EM<br />
 +
**[[7d4i]] – yDhr1 in 90S ribosome – Cryo EM<br />
 +
**[[6h57]] – yDhr1 <br />
**[[6zwx]] – EcHrpA<br />
**[[6zwx]] – EcHrpA<br />
**[[7akp]] – EcHrpA (mutant)<br />
**[[7akp]] – EcHrpA (mutant)<br />
Line 299: Line 307:
**[[6c90]] - hDOB1 residues 70-600 + ZCCHC8<br />
**[[6c90]] - hDOB1 residues 70-600 + ZCCHC8<br />
**[[6d6r]], [[6d6q]] - hDOB1 in exosome + RNA – Cryo EM<br />
**[[6d6r]], [[6d6q]] - hDOB1 in exosome + RNA – Cryo EM<br />
 +
**[[7z4y]] – hMTR4 in exosome – Cryo EM<br />
 +
**[[5z3g]], [[6c0f]], [[6cb1]], [[6em3]], [[6em4]], [[6em5]], [[7r6q]], [[7r72]], [[8e5t]], [[8etg]], [[8eti]], [[8euy]], [[8ev3]] - yHas1 in 60S ribosome biogenesis intermediate + RNA – Cryo EM<br />
**[[2xzl]] – yNAM7 CH and helicase domains + RNA<BR />
**[[2xzl]] – yNAM7 CH and helicase domains + RNA<BR />
**[[2xgj]] – yDOB1 residues 81-1073 + RNA<BR />
**[[2xgj]] – yDOB1 residues 81-1073 + RNA<BR />
Line 306: Line 316:
**[[5suq]] – ySUB2 + TEX1 + THO2 <br />
**[[5suq]] – ySUB2 + TEX1 + THO2 <br />
**[[5sup]] – ySUB2 + YRA1 + RNA <br />
**[[5sup]] – ySUB2 + YRA1 + RNA <br />
 +
**[[7apx]], [[7luv]], [[7v2y]] – ySUB2 in THO complex – Cryo EM <br />
**[[2vso]], [[2vsx]] – yEIF4A + initiation factor 4F middle domain<BR />
**[[2vso]], [[2vsx]] – yEIF4A + initiation factor 4F middle domain<BR />
**[[2g9n]] - hEIF4A dead domain
**[[2g9n]] - hEIF4A dead domain
Line 311: Line 322:
*Viral ATP-dependent RNA helicase NS3
*Viral ATP-dependent RNA helicase NS3
-
**[[3o8b]], [[3o8d]], [[1cu1]], [[8ohm]], [[1hei]], [[4a92]], [[3rvb]] – HvHel NS3 residues 1186-1658 – Hepatitis C virus<BR />
+
**[[3o8b]], [[3o8d]], [[1cu1]], [[8ohm]], [[1hei]], [[4a92]], [[3rvb]], [[5wdx]] – HvHel NS3 residues 1186-1658 – Hepatitis C virus<BR />
**[[1onb]], [[1jr6]] - HvHel NS3 arginine-rich domain residues 1353-1507 – NMR<BR />
**[[1onb]], [[1jr6]] - HvHel NS3 arginine-rich domain residues 1353-1507 – NMR<BR />
**[[2jlq]], [[2bhr]], [[2bmf]], [[2whx]], [[2wzq]] – DvHel NS3 residues 1646-2092 – Dengue virus<BR />
**[[2jlq]], [[2bhr]], [[2bmf]], [[2whx]], [[2wzq]] – DvHel NS3 residues 1646-2092 – Dengue virus<BR />
Line 318: Line 329:
**[[2v8o]], [[2wv9]] - Hel NS3 helicase domain – Murray valley encephalitis virus<BR />
**[[2v8o]], [[2wv9]] - Hel NS3 helicase domain – Murray valley encephalitis virus<BR />
**[[2qeq]] - Hel NS3 residues 1691-2124 – Kunjin virus<BR />
**[[2qeq]] - Hel NS3 residues 1691-2124 – Kunjin virus<BR />
-
**[[5txg]], [[5jmt]], [[5vi7]], [[5jps]], [[6mh3]] - ZvHel NS3 helicase domain – Zika virus<br />
+
**[[5txg]], [[5jmt]], [[5rhy]], [[5vi7]], [[5jps]], [[6adw]], [[6mh3]] - ZvHel NS3 helicase domain 1674-2119 – Zika virus<br />
**[[5k8u]], [[5k8l]], [[5k8i]], [[5jwh]], [[5jrz]] - ZvHel NS3 residues 164-621<br />
**[[5k8u]], [[5k8l]], [[5k8i]], [[5jwh]], [[5jrz]] - ZvHel NS3 residues 164-621<br />
**[[5x8y]] - ZvHel NS1 residues 168-352<br />
**[[5x8y]] - ZvHel NS1 residues 168-352<br />
Line 324: Line 335:
**[[2v6j]] - KvHel helicase domain (mutant)<br />
**[[2v6j]] - KvHel helicase domain (mutant)<br />
**[[5wso]], [[5gvu]] - Hel NS3 residues 1939-2414 – bovine viral diarrhea virus<br />
**[[5wso]], [[5gvu]] - Hel NS3 residues 1939-2414 – bovine viral diarrhea virus<br />
 +
**[[1yks]], [[5ffm]] - Hel NS3 helicase domain – yellow fever virus<br />
 +
**[[7wd4]] - Hel NS3 helicase domain – ilheus virus<br />
 +
**[[4cbg]], [[4cbh]], [[4cbi]], [[4cbl]], [[4cbm]] - Hel NS3 helicase domain – pestivirus<br />
 +
**[[7nno]], [[7oj4]] - TbevHel NS3 helicase domain – Tick-bourne encephalitis virus<br />
*''Viral ATP-dependent RNA helicase NS3 complexes''
*''Viral ATP-dependent RNA helicase NS3 complexes''
**[[3o8c]], [[3o8r]], [[3kqh]], [[3kqk]], [[3kql]], [[3kqn]], [[3kqu]], [[1a1v]] - HvHel NS3 + RNA<BR />
**[[3o8c]], [[3o8r]], [[3kqh]], [[3kqk]], [[3kql]], [[3kqn]], [[3kqu]], [[1a1v]] - HvHel NS3 + RNA<BR />
 +
**[[2f55]] - HvHel NS3 + DNA<br />
**[[2f9v]] - HvHel NS3 protease domain + polyprotein<BR />
**[[2f9v]] - HvHel NS3 protease domain + polyprotein<BR />
**[[2a4g]], [[1rtl]], [[1w3c]], [[1dxp]] - HvHel NS3 protease domain + NS4A peptide<BR />
**[[2a4g]], [[1rtl]], [[1w3c]], [[1dxp]] - HvHel NS3 protease domain + NS4A peptide<BR />
 +
**[[2zjo]], [[4ok5]], [[4oks]], [[4wxp]], [[4wxr]] - HvHel NS3 + inhibitor<br />
 +
**[[5e4f]] - HvHel NS3 + ADP<br />
**[[2a4q]], [[2a4r]], [[2f9u]], [[2fm2]], [[1dy8]], [[1dy9]] - HvHel NS3 protease domain + NS4A peptide + inhibitor<BR />
**[[2a4q]], [[2a4r]], [[2f9u]], [[2fm2]], [[1dy8]], [[1dy9]] - HvHel NS3 protease domain + NS4A peptide + inhibitor<BR />
-
**[[2jlr]] - DvHel NS3 residues 1646-2092 + AMPPNP<BR />
+
**[[2jlr]] - DvHel NS3 helicase domain + AMPPNP<BR />
-
**[[2jls]] - DvHel NS3 residues 1646-2092 + ADP<BR />
+
**[[2jls]] - DvHel NS3 helicase domain + ADP<BR />
-
**[[2jlu]], [[2jlw]], [[5xc6]] - DvHel NS3 residues 1646-2092 + RNA<BR />
+
**[[2jlu]], [[2jlw]], [[5xc6]] - DvHel NS3 helicase domain + RNA<BR />
-
**[[2jlv]] - DvHel NS3 residues 1646-2092 + AMPPNP + RNA<BR />
+
**[[2jlv]] - DvHel NS3 helicase domain + AMPPNP + RNA<BR />
-
**[[2jlx]], [[2jly]], [[2jlz]] - DvHel NS3 residues 1646-2092 + ADP + RNA<BR />
+
**[[2jlx]], [[2jly]], [[2jlz]] - DvHel NS3 helicase domain + ADP + RNA<BR />
-
**[[2vbc]] - DvHel NS3 residues 1475-2092 + NS2A peptide<br />
+
**[[2vbc]] - DvHel NS3 residues helicase domain + NS2A peptide<br />
**[[5k8t]] - ZvHel NS3 residues 164-621 + GTP<br />
**[[5k8t]] - ZvHel NS3 residues 164-621 + GTP<br />
-
**[[5gjc]] - ZvHel NS3 residues 1676-2119 + ATP<br />
+
**[[5gjc]] - ZvHel NS3 helicase domain + ATP<br />
-
**[[5gjb]] - ZvHel NS3 residues 1676-2119 + RNA<br />
+
**[[5gjb]] - ZvHel NS3 helicase domain + RNA<br />
-
**[[5y4z]] - ZvHel NS3 residues 1676-2119 + AMPPNP<br />
+
**[[5y4z]] - ZvHel NS3 helicase domain + AMPPNP<br />
 +
**[[5rhg]], ]]5rhh]], [[5rhi]], [[5rhj]], [[5rhk]], [[5rhl]], [[5rhm]], [[5rho]], [[5rhp]], [[5rhq]], [[5rhr]], [[5rhs]], [[5rht]], [[5rhu]], [[5rhv]], [[5rhw]], [[5rhx]] - ZvHel NS3 helicase domain + inhibitor<br />
 +
**[[5y6m]], [[5y6n]], [[6adx]], [[6ady]], [[6rwz]], [[6s0j]] - ZvHel NS3 helicase domain + ADP<br />
 +
**[[7blv]], [[7nxu]] - TbevHel NS3 helicase domain + ADP <br />
 +
**[[7bm0]] - TbevHel NS3 helicase domain + AMPPNP <br />
 +
**[[6jim]] - Hel NS3 helicase domain + RNA – chikungunya virus<br />
*ATP-dependent RNA helicase SUV3
*ATP-dependent RNA helicase SUV3
-
**[[3rc3]] – hSUV3 residues 47-722<BR />
+
**[[3rc3]], [[7w1r]] – hSUV3 residues 47-722<BR />
**[[3og8]] – hDDX58 C terminal + RNA<BR />
**[[3og8]] – hDDX58 C terminal + RNA<BR />
**[[3rc8]] - hSUV3 residues 47-722 + RNA<BR />
**[[3rc8]] - hSUV3 residues 47-722 + RNA<BR />
Line 377: Line 400:
**[[4bru]] – yDhh1 (mutant) + EDC3<br />
**[[4bru]] – yDhh1 (mutant) + EDC3<br />
**[[4brw]] – yDhh1 (mutant) + PAT1<br />
**[[4brw]] – yDhh1 (mutant) + PAT1<br />
 +
**[[1s2m]] – yDhh1p<br />
*Werner syndrome ATP-dependent DNA helicase
*Werner syndrome ATP-dependent DNA helicase
Line 396: Line 420:
**[[5lb5]], [[5lb3]] – hQ5 + ADP<br />
**[[5lb5]], [[5lb3]] – hQ5 + ADP<br />
**[[5lba]] – hQ5 + urea derivative<br />
**[[5lba]] – hQ5 + urea derivative<br />
 +
**[[7zml]], [[7zmm]], [[7zmn]], [[7zmp]], [[7zmq]], [[7zmt]], [[7zmv]] – hQ5 + nanobody<br />
*ATP-dependent DNA helicase RecG
*ATP-dependent DNA helicase RecG
Line 428: Line 453:
**[[1in5]], [[1in6]], [[1in7]], [[1in8]], [[1j7k]] – TmRuvB (mutant)<br />
**[[1in5]], [[1in6]], [[1in7]], [[1in8]], [[1j7k]] – TmRuvB (mutant)<br />
**[[3pfi]] – RuvB + ADP – ''Campylobacter jejuni''<br />
**[[3pfi]] – RuvB + ADP – ''Campylobacter jejuni''<br />
-
**[[6blb]] - PaRuvB + ADP - ''Pseudomonas aeruginosa''<br />
+
**[[6blb]], [[7x5b]] - PaRuvB + ADP - ''Pseudomonas aeruginosa''<br />
 +
**[[7x5a]], [[7x7p]], [[7x7q]] - PaRuvB in Holliday junciton – Cryo EM<br />
 +
**[[7pbl]], [[7pbm]], [[7pbn]], [[7pbo]], [[7pbp]], [[7pbq]], [[7pbr]], [[7pbs]], [[7pbt]], [[7pbu]] – RuvA + RuvB + DNA – Streptococcus thermophiles – Cryo EM<br />
*ATP-dependent DNA helicase RuvB-like
*ATP-dependent DNA helicase RuvB-like
Line 462: Line 489:
**[[2d7e]] – EcPriA DNA-binding domain<BR />
**[[2d7e]] – EcPriA DNA-binding domain<BR />
-
**[[2d7g]], [[2d7h]], [[2dwl]], [[2dwm]], [[2dwn]] – EcPriA N terminal + polynucleotide
+
**[[2d7g]], [[2d7h]], [[2dwl]], [[2dwm]], [[2dwn]] – EcPriA N terminal + polynucleotide<br />
 +
**[[6dgd]] – KpPriA + DNA – ''Klebsiella pneumoniae''<br />
 +
**[[4nl4]] – KpPriA + ADP<br />
 +
**[[4nl8]] – KpPriA + peptide<br />
*ATP-dependent DNA helicase PcrA
*ATP-dependent DNA helicase PcrA
Line 474: Line 504:
*DnaB helicase or replicative DNA helicase
*DnaB helicase or replicative DNA helicase
-
**[[3gxv]] – HpDnaB – ''Helicobacter pylori''<BR />
+
**[[3gxv]], [[4zc0]] – HpDnaB – ''Helicobacter pylori''<BR />
**[[4a1f]] – HpDnaB C terminal<br />
**[[4a1f]] – HpDnaB C terminal<br />
**[[2r6d]] – BsDnaB – ''Bacillus stearothermophilus''<BR />
**[[2r6d]] – BsDnaB – ''Bacillus stearothermophilus''<BR />
Line 485: Line 515:
**[[6frg]], [[6fre]] – SyDnaB (mutant) <br />
**[[6frg]], [[6fre]] – SyDnaB (mutant) <br />
**[[6bbm]] – EcDnaB + replication protein P – Cryo EM<br />
**[[6bbm]] – EcDnaB + replication protein P – Cryo EM<br />
 +
**[[7t21]] – EcDnaB + DNA + ADP – Cryo EM<br />
 +
**[[7t22]], [[7t23]] – EcDnaB (mutant) + DNA primase + DNA + ADP – Cryo EM<br />
**[[1b79]] - EcDnaB N terminal<BR />
**[[1b79]] - EcDnaB N terminal<BR />
**[[1jwe]] - EcDnaB N terminal - NMR<BR />
**[[1jwe]] - EcDnaB N terminal - NMR<BR />
**[[6kza]] - EcDnaB C terminal + DnaC<br />
**[[6kza]] - EcDnaB C terminal + DnaC<br />
 +
**[[7t20]] - EcDnaB + DNA + AMPPNP<br />
 +
**[[4esv]] – BsDnaB + DNA<br />
 +
**[[4m4w]] – BsDnaB in primosome <br />
**[[2r6c]], [[2r6a]] – BsDnaB + DnaG helicase-binding domain<br />
**[[2r6c]], [[2r6a]] – BsDnaB + DnaG helicase-binding domain<br />
**[[6bs8]], [[6own]] – MsDnaB 238-376<br />
**[[6bs8]], [[6own]] – MsDnaB 238-376<br />
**[[6rix]], [[6riy]] – DnaB (mutant) – ''Mycobacterium chimaera''<br />
**[[6rix]], [[6riy]] – DnaB (mutant) – ''Mycobacterium chimaera''<br />
**[[6own]], [[6bs8]] – MsDnaB 238-376<br />
**[[6own]], [[6bs8]] – MsDnaB 238-376<br />
-
**[[6t66]] – DnaB + GDP – Vibrio cholerae<br />
+
**[[7qxm]] – VcDnaB – ''Vibrio cholerae''<br />
 +
**[[6t66]] – VcDnaB + GDP <br />
 +
**[[8a3v]] – VcDnaB + DCIA<br />
 +
**[[4nmn]] – AaDnaB + ADP – ''Aquifex aeolicus''<br />
*DnaC helicase
*DnaC helicase
Line 498: Line 536:
**[[2vyf]]– GkDnaC – ''Geobacillus kaustophilus''<br />
**[[2vyf]]– GkDnaC – ''Geobacillus kaustophilus''<br />
**[[2vye]] – GkDnaC + DNA <br />
**[[2vye]] – GkDnaC + DNA <br />
-
**[[3ec2]] – AaDnaC – ''Aquifex aeolicus''<br />
+
**[[3ec2]] – AaDnaC <br />
**[[3ecc]] – AaDnaC + ADP<br />
**[[3ecc]] – AaDnaC + ADP<br />
**[[6qel]] – EcDnaC + replicative DNA Hel - Cryo EM<br />
**[[6qel]] – EcDnaC + replicative DNA Hel - Cryo EM<br />
Line 505: Line 543:
*Helicase BLM
*Helicase BLM
-
**[[5lup]] – hBLM DHBN domain <br />
+
**[[7auc]] – hBLM 636-1298<br />
 +
**[[7aud]] – hBLM 636-1298 + DNA<br />
 +
**[[5lup]], [[5mk5]] – hBLM DHBN domain 362-414<br />
 +
**[[2mh9]], [[3we2]], [[3we3]] – hBLM RQC domain 1068-1209<br />
 +
**[[2kv2]] – hBLM HRDC domain 1210-1294 - NMR<br />
**[[5lut]] – BLM DHBN domain - chicken<br />
**[[5lut]] – BLM DHBN domain - chicken<br />
**[[5lus]] – BLM DHBN domain - pelican<br />
**[[5lus]] – BLM DHBN domain - pelican<br />
Line 512: Line 554:
**[[4w7s]] – yCa8<br />
**[[4w7s]] – yCa8<br />
 +
**[[5dtu]] – CtPrp28 + ADP<br />
*Helicase NSP see [[Nonstructural protein]]
*Helicase NSP see [[Nonstructural protein]]
Line 526: Line 569:
*Helicase SNF2
*Helicase SNF2
 +
**[[5x0x]], [[5x0y]], [[5z3o]], [[5z3u]], [[5z3v]], [[6iy2]], [[6iy3]], [[6uxw]], [[7c4j]], [[7egm]], [[7egp]] – ySNF2 in nucleosome – Cryo EM<br />
**[[1z5z]] – SsSNF2 C terminal – ''Sulfolobus solfataricus''<br />
**[[1z5z]] – SsSNF2 C terminal – ''Sulfolobus solfataricus''<br />
**[[1z63]] - SsSNF2 ATPase core + DNA<br />
**[[1z63]] - SsSNF2 ATPase core + DNA<br />
Line 532: Line 576:
*Helicase SKI2
*Helicase SKI2
 +
**[[7qdy]], [[7qdz]], [[7qe0]] – hSKI2W + TPR repeat protein + SKI8 + RNA – Cryo EM<br />
 +
**[[7qdr]], [[7qds]] – hSKI2W + TPR repeat protein + SKI8 – Cryo EM<br />
 +
**[[4buj]] – ySKI2 + superkiller protein + SKI8 <br />
**[[4a4k]] – ySKI2 insertion domain<br />
**[[4a4k]] – ySKI2 insertion domain<br />
**[[4a4z]] – ySKI2 + AMPPNP<br />
**[[4a4z]] – ySKI2 + AMPPNP<br />
Line 548: Line 595:
**[[5ivw]] - hXPD + XPB + TFIIH ubunits 2,3,4,5 + SCP-X + SCP-Ybr />
**[[5ivw]] - hXPD + XPB + TFIIH ubunits 2,3,4,5 + SCP-X + SCP-Ybr />
-
*Pre-mRNA-splicing Helicase or Brr2
+
*Pre-mRNA-splicing Helicase or Brr2 or ski2-like
-
**[[6s8o]] – hBrr2 394-2136 (mutant)<br />
+
**[[4f92]] – hBrr2 402-2125<br />
-
**[[6s8q]], [[6s9i]] – hBrr2 394-2136 + pre-mRNA-splicing factor 8<br />
+
**[[4f91]] – hBrr2 helicase region 394-213<br />
 +
**[[6s8o]] – hBrr2 helicase region (mutant)<br />
 +
**[[4f93]] – hBrr2 helicase region (mutant) + ATP + ADP<br />
 +
**[[8bch]] – hBrr2 helicase region + sulfaguanidine<br />
 +
**[[5urj]], [[5urk]], [[5urm]] – hBrr2 helicase region + inhibitor<br />
 +
**[[4kit]], [[6s8q]], [[6s9i]], [[8bc9]] – hBrr2 helicase region + pre-mRNA-splicing factor 8<br />
 +
**[[8bc8]], [[8bcb]], [[8bcc]], [[8bcd]], [[8bcf]] , [[8bcg]] – hBrr2 helicase region + pre-mRNA-splicing factor 8 + inhibitor<br />
 +
**[[7os2]] – hBrr2 helicase region + pre-mRNA-splicing factor 8 + telomere length and silencing protein – Cryo EM<br />
 +
**[[7os1]] – hBrr2 helicase region + WBP-4 – Cryo EM<br />
 +
**[[7px3]] – hBrr2 helicase region + pre-mRNA-splicing factor 8 + TSSC4 – Cryo EM<br />
 +
**[[3jcm]], [[3jcr]], [[5gap]] – hBrr2 helicase region in U4/U6.U5 snRNP complex – Cryo EM<br />
**[[7bdi]], [[7bdj]], [[7bdk]], [[7bdl]] – hBrr2 394-2136 + pre-mRNA-splicing factor 8 + nucleotide<br />
**[[7bdi]], [[7bdj]], [[7bdk]], [[7bdl]] – hBrr2 394-2136 + pre-mRNA-splicing factor 8 + nucleotide<br />
**[[3hib]], [[3im1]], [[3im2]] – yBrr2 2nd SEC63 domain<br />
**[[3hib]], [[3im1]], [[3im2]] – yBrr2 2nd SEC63 domain<br />
**[[4bgd]], [[5m5p]], [[5m52]], [[5dca]] – yBrr2 + pre-mRNA-splicing factor 8<br />
**[[4bgd]], [[5m5p]], [[5m52]], [[5dca]] – yBrr2 + pre-mRNA-splicing factor 8<br />
-
**[[6qws]] – CtBrr2 <br />
+
**[[5gan]], [[5gao]] – yBrr2 in U4/U6.U5 complex – Cryo EM<br />
 +
**[[5lj5]], [[5lqw]] – yBrr2 in spliceosome – Cryo EM<br />
 +
**[[6qws]] – CtBrr2 473-2193<br />
 +
**[[4rvq]] – CtBrr2 PWI-like domain 287-422<br />
**[[6qv4]] – CtBrr2 + ATPgS<br />
**[[6qv4]] – CtBrr2 + ATPgS<br />
 +
**[[6qv3]] – CtBrr2 + ADP<br />
*crispr-associated helicase Cas3
*crispr-associated helicase Cas3
Line 568: Line 629:
**[[5gqh]] – PaCas3 + anti-crispr protein 3 <br />
**[[5gqh]] – PaCas3 + anti-crispr protein 3 <br />
**[[5b7i]] – PaCas3 + ACRF3<br />
**[[5b7i]] – PaCas3 + ACRF3<br />
 +
 +
*Helicase aquarius or intron-binding protein aquarius
 +
 +
**[[4pj3]] – hHA + AMPPNP <br />
 +
**[[6id0]], [[6id1]] – hHA in spliceosome – Cryo EM<br />
 +
**[[3jb9]] – fyHA in spliceosome – Cryo EM<br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D structures of helicase

Updated on 10-May-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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