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8jaa
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8jaa is ON HOLD Authors: Zhang, B., Liang, J., Rao, Z. Description: Crystal structure of Mycobacterium tuberculosis LpqY in complex with trehalose ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Mycobacterium tuberculosis LpqY in complex with trehalose analogue YB-04== | |
| - | + | <StructureSection load='8jaa' size='340' side='right'caption='[[8jaa]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8jaa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JAA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TY6:(2~{S},3~{R},4~{S},5~{S},6~{S})-6-[(2-azanylhydrazinyl)methyl]oxane-2,3,4,5-tetrol'>TY6</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jaa OCA], [https://pdbe.org/8jaa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jaa RCSB], [https://www.ebi.ac.uk/pdbsum/8jaa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jaa ProSAT]</span></td></tr> |
| - | [[Category: Liang | + | </table> |
| - | [[Category: Rao | + | == Function == |
| + | [https://www.uniprot.org/uniprot/LPQY_MYCTU LPQY_MYCTU] Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence.<ref>PMID:21118978</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
| + | [[Category: Liang J]] | ||
| + | [[Category: Rao Z]] | ||
| + | [[Category: Zhang B]] | ||
Current revision
Crystal structure of Mycobacterium tuberculosis LpqY in complex with trehalose analogue YB-04
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