1kt9

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[[Image:1kt9.jpg|left|200px]]
 
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==Crystal Structure of C. elegans Ap4A Hydrolase==
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The line below this paragraph, containing "STRUCTURE_1kt9", creates the "Structure Box" on the page.
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<StructureSection load='1kt9' size='340' side='right'caption='[[1kt9]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kt9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KT9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KT9 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kt9 OCA], [https://pdbe.org/1kt9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kt9 RCSB], [https://www.ebi.ac.uk/pdbsum/1kt9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kt9 ProSAT]</span></td></tr>
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{{STRUCTURE_1kt9| PDB=1kt9 | SCENE= }}
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</table>
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== Function ==
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'''Crystal Structure of C. elegans Ap4A Hydrolase'''
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[https://www.uniprot.org/uniprot/AP4A_CAEEL AP4A_CAEEL] Asymmetrically hydrolyzes Ap4A to yield AMP and ATP.<ref>PMID:11738085</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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The crystal structure of C. elegans Ap(4)A hydrolase has been determined for the free enzyme and a binary complex at 2.0 A and 1.8 A, respectively. Ap(4)A hydrolase has a key role in regulating the intracellular Ap(4)A levels and hence potentially the cellular response to metabolic stress and/or differentiation and apoptosis via the Ap(3)A/Ap(4)A ratio. The structures reveal that the enzyme has the mixed alpha/beta fold of the Nudix family and also show how the enzyme binds and locates its substrate with respect to the catalytic machinery of the Nudix motif. These results suggest how the enzyme can catalyze the hydrolysis of a range of related dinucleoside tetraphosphate, but not triphosphate, compounds through precise orientation of key elements of the substrate.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/1kt9_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1KT9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KT9 OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kt9 ConSurf].
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The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms., Bailey S, Sedelnikova SE, Blackburn GM, Abdelghany HM, Baker PJ, McLennan AG, Rafferty JB, Structure. 2002 Apr;10(4):589-600. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11937063 11937063]
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Abdelghany, H M.]]
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[[Category: Abdelghany HM]]
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[[Category: Bailey, S.]]
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[[Category: Bailey S]]
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[[Category: Baker, P J.]]
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[[Category: Baker PJ]]
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[[Category: Blackburn, G M.]]
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[[Category: Blackburn GM]]
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[[Category: McLennan, A G.]]
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[[Category: McLennan AG]]
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[[Category: Rafferty, J B.]]
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[[Category: Rafferty JB]]
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[[Category: Sedelnikova, S E.]]
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[[Category: Sedelnikova SE]]
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[[Category: Crystal structure]]
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[[Category: Nudix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:08:46 2008''
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Current revision

Crystal Structure of C. elegans Ap4A Hydrolase

PDB ID 1kt9

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