Hydroxylases 3D structures

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**[[2v27]], [[2v28]] – PAH – ''Colwellia psychrerythraea''<br />
**[[2v27]], [[2v28]] – PAH – ''Colwellia psychrerythraea''<br />
**[[1ltu]], [[1ltv]] – CvPAH – ''Chromobacterium violaceum''<br />
**[[1ltu]], [[1ltv]] – CvPAH – ''Chromobacterium violaceum''<br />
-
**[[4bpt]] – PAH –'' Legionella pneumophila''<br />
+
**[[4bpt]] – PAH – ''Legionella pneumophila''<br />
**[[1ltz]] - CvPAH + cofactor<br />
**[[1ltz]] - CvPAH + cofactor<br />
**[[3tcy]], [[3tk2]] – CvPAH + phenylalanine<br />
**[[3tcy]], [[3tk2]] – CvPAH + phenylalanine<br />
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**[[4jpx]] - CvPAH (mutant) + Co + phenylalanine<br />
**[[4jpx]] - CvPAH (mutant) + Co + phenylalanine<br />
**[[4jpy]] - CvPAH + Fe + phenylalanine<br />
**[[4jpy]] - CvPAH + Fe + phenylalanine<br />
-
**[[7vgm]] - PAH + Fe – Bacillus cereus<br />
+
**[[7vgm]] - PAH + Fe – ''Bacillus cereus''<br />
*Tyrosine hydroxylase (cofactor tetrahydrobiopterin)
*Tyrosine hydroxylase (cofactor tetrahydrobiopterin)
Line 42: Line 42:
**[2toh]], [[1toh]] – rTH catalytic and tetramerization domains 160-498 – rat
**[2toh]], [[1toh]] – rTH catalytic and tetramerization domains 160-498 – rat
**[[2mda]] – rTH regulatory domain 65-159 – NMR<br />
**[[2mda]] – rTH regulatory domain 65-159 – NMR<br />
-
**[[7kqr]], [[7kqs]], [[7kqt]], [[7kqu]] – TH + heme + Tyr derivative – Streptomyces sclerotialus <br />
+
**[[7kqr]], [[7kqs]], [[7kqt]], [[7kqu]] – TH + heme + Tyr derivative – ''Streptomyces sclerotialus'' <br />
*Tryptophan hydroxylase
*Tryptophan hydroxylase
**[[7wiy]] – hTPH 2 + Fe – Cryo EM<br />
**[[7wiy]] – hTPH 2 + Fe – Cryo EM<br />
-
**[[3hf8]], [[3hfb]], [[3hf6]], [[5tpg]], [[5l01]], [[5j6d]], [[7zig]], [[7zih]], [[7zif]], [[7zii]], [[7zij]], [[7zik]] – hTPH 1 catalytic domain 105-401 + inhibitor + Fe <br />
+
**[[3hf8]], [[3hfb]], [[3hf6]], [[5tpg]], [[5l01]], [[5j6d]], [[7zig]], [[7zih]], [[7zif]], [[7zii]], [[7zij]], [[9he3]] – hTPH 1 catalytic domain 105-401 + inhibitor + Fe <br />
**[[1mlw]] – hTPH catalytic domain+ biopterin + Fe<br />
**[[1mlw]] – hTPH catalytic domain+ biopterin + Fe<br />
**[[4v06]] - hTPH 2 catalytic domain + Fe<br />
**[[4v06]] - hTPH 2 catalytic domain + Fe<br />
Line 72: Line 72:
**[[1k0j]] – PaPHBH (mutant) + FAD + NADPH <br />
**[[1k0j]] – PaPHBH (mutant) + FAD + NADPH <br />
**[[1k0l]] – PaPHBH (mutant) + FAD <br />
**[[1k0l]] – PaPHBH (mutant) + FAD <br />
-
**[[5tti]], [[6dll]] – PfPHBH + FAD – ''Pseudomonas putida''<br />
+
**[[6dll]] – PfPHBH + FAD – ''Pseudomonas putida''<br />
-
**[[2dki]] – CtPHBH + FAD – Comamonas testosteroni<br />
+
**[[2dki]] – CtPHBH + FAD – ''Comamonas testosteroni''<br />
**[[2dkh]] – CtPHBH + FAD + hydroxy-benzoate <br />
**[[2dkh]] – CtPHBH + FAD + hydroxy-benzoate <br />
Line 84: Line 84:
**[[6yyu]], [[6yyv]] – hAAH oxygenase and TPR domain + oxoglutarate + Mn <br />
**[[6yyu]], [[6yyv]] – hAAH oxygenase and TPR domain + oxoglutarate + Mn <br />
**[[6yyw]], [[6yyx]], [[6yyy]], [[6z6q]] – hAAH oxygenase and TPR domain + oxoglutarate + Mn + coagulation factor X peptide<br />
**[[6yyw]], [[6yyx]], [[6yyy]], [[6z6q]] – hAAH oxygenase and TPR domain + oxoglutarate + Mn + coagulation factor X peptide<br />
-
**[[5jz8]], [[5jzu]], [[5jzz]], [[5jqy]], [[6rk9]], [[6z6r]] – hAAH oxygenase and TPR domain + oxalyl derivative + Mn + coagulation factor X peptide<br />
+
**[[5jz8]], [[5jzu]], [[6rk9]], [[5jqy]], [[6z6r]] – hAAH oxygenase and TPR domain + oxalyl derivative + Mn + coagulation factor X peptide<br />
**[[7e6j]] – hAAH oxygenase and TPR domain (mutant) + coagulation factor X peptide<br />
**[[7e6j]] – hAAH oxygenase and TPR domain (mutant) + coagulation factor X peptide<br />
**[[6q9f]], [[6q9i]] – hAAH oxygenase and TPR domain (mutant) + oxalylglycine + Mn + coagulation factor X peptide<br />
**[[6q9f]], [[6q9i]] – hAAH oxygenase and TPR domain (mutant) + oxalylglycine + Mn + coagulation factor X peptide<br />
Line 91: Line 91:
*Alpha-ketoglutarate-dependent L-arginine hydroxylase
*Alpha-ketoglutarate-dependent L-arginine hydroxylase
-
**[[6dax]], [[6alm]], [[6aln]], [[6mp8]] – SvAAH + arginine + oxoglutarate + Fe – Streptomyces vinaceus<br />
+
**[[6dax]], [[6alm]], [[6aln]], [[6mp8]] – SvAAH + arginine + oxoglutarate + Fe – ''Streptomyces vinaceus''<br />
**[[6daz]], [[6alo]], [[6alp]], [[6alq]], [[6y12]] – SvAAH + arginine + succinate + Fe <br />
**[[6daz]], [[6alo]], [[6alp]], [[6alq]], [[6y12]] – SvAAH + arginine + succinate + Fe <br />
**[[6y0n]] – SvAAH + arginine + AKG + Fe <br />
**[[6y0n]] – SvAAH + arginine + AKG + Fe <br />
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*PLP-dependent L-arginine hydroxylase
*PLP-dependent L-arginine hydroxylase
-
**[[6c9b]] – SwAAH + PLP – Streptomyces wadayamensis<br />
+
**[[6c9b]] – SwAAH + PLP – ''Streptomyces wadayamensis''<br />
**[[5dj1]] – SwAAH + PLP + Mg<br />
**[[5dj1]] – SwAAH + PLP + Mg<br />
**[[5dj3]] – SwAAH + PLP-arginine + Mg<br />
**[[5dj3]] – SwAAH + PLP-arginine + Mg<br />
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*Leucine hydroxylase
*Leucine hydroxylase
-
**[[5nch]] – StAAH – Streptomyces <br />
+
**[[5nch]] – StAAH – ''Streptomyces'' <br />
**[[5nci]] – StAAH + leucine derivative + oxoglutarate + Co <br />
**[[5nci]] – StAAH + leucine derivative + oxoglutarate + Co <br />
**[[5ncj]] – StAAH + leucine derivative + succinate + Mn <br />
**[[5ncj]] – StAAH + leucine derivative + succinate + Mn <br />
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*L-arginine b-hydroxylase or non-heme iron oxygenase
*L-arginine b-hydroxylase or non-heme iron oxygenase
-
**[[4m23]] – SlORFP – Streptomyces lavendulae<br />
+
**[[4m23]] – SlORFP – ''Streptomyces lavendulae''<br />
**[[4m2i]] – SlORFP + Fe <br />
**[[4m2i]] – SlORFP + Fe <br />
**[[4m25]] – SlORFP + Fe + ketoglutarate <br />
**[[4m25]] – SlORFP + Fe + ketoglutarate <br />
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**[[4m2f]] – SlORFP + Fe + canavanine<br />
**[[4m2f]] – SlORFP + Fe + canavanine<br />
**[[4m2g]], [[4m26]] – SlORFP + Fe + succinate + Arg derivative<br />
**[[4m2g]], [[4m26]] – SlORFP + Fe + succinate + Arg derivative<br />
-
**[[2wbo]] – SvVIOC + Fe + Arg – Streptomyces vinaceus<br />
+
**[[2wbo]] – SvVIOC + Fe + Arg – ''Streptomyces vinaceus''<br />
**[[2wbq]] – SvVIOC + Arg derivative<br />
**[[2wbq]] – SvVIOC + Arg derivative<br />
**[[2wbp]] – SvVIOC + Fe + succinate + Arg derivative<br />
**[[2wbp]] – SvVIOC + Fe + succinate + Arg derivative<br />
-
**[[6daw]] – NAPI + Fe + Arg – Streptomyces lusitanus<br />
+
**[[6daw]] – NAPI + Fe + Arg – ''Streptomyces lusitanus''<br />
*Prolyl 4-hydroxylase
*Prolyl 4-hydroxylase
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**[[6evl]] - hPH a2 subunit <br />
**[[6evl]] - hPH a2 subunit <br />
**[[6evm]], [[6evn]], [[6evo]], [[6evp]] - hPH a2 subunit + peptide<br />
**[[6evm]], [[6evn]], [[6evo]], [[6evp]] - hPH a2 subunit + peptide<br />
-
**[[3itq]], [[5hv0]] - BaPH – Bacillus anthracis <br />
+
**[[3itq]], [[5hv0]] - BaPH – ''Bacillus anthracis'' <br />
**[[5hv4]] - BaPH + ketoglutarate<br />
**[[5hv4]] - BaPH + ketoglutarate<br />
**[[5c5u]] - PcvPH + Mn – Paramecium chlorella virus <br />
**[[5c5u]] - PcvPH + Mn – Paramecium chlorella virus <br />
**[[5c5t]] - PcvPH + Mn + Zn <br />
**[[5c5t]] - PcvPH + Mn + Zn <br />
-
**[[4p7x]] - RlPH + Co + pipecolic acid – Rhizobium loti <br />
+
**[[4p7x]] - RlPH + Co + pipecolic acid – ''Rhizobium loti'' <br />
**[[4p7w]] - RlPH + Co + proline<br />
**[[4p7w]] - RlPH + Co + proline<br />
-
**[[6iuq]] - PH + Fe – Phytophthora capsici<br />
+
**[[6iuq]] - PH + Fe – ''Phytophthora capsici''<br />
-
**[[2v4a]], [[2jij]] - CrPH – Chlamydomonas reinhardtii <br />
+
**[[2v4a]], [[2jij]] - CrPH – ''Chlamydomonas reinhardtii'' <br />
**[[2jig]] - CrPH + Zn + pyridine derivative<br />
**[[2jig]] - CrPH + Zn + pyridine derivative<br />
**[[3gze]] - CrPH + Zn + peptide<br />
**[[3gze]] - CrPH + Zn + peptide<br />
-
*HIF prolyl hydroxylase or egl nine homolog
+
*HIF prolyl hydroxylase or egl nine homolog See [[Prolyl hydroxylase domain]]
-
 
+
-
See [[Prolyl hydroxylase domain]]
+
*Lysine 4-hydroxylase
*Lysine 4-hydroxylase
-
**[[6f9p]] – FlL4H + Fe – Flavobacterium <br />
+
**[[6f9p]] – FlL4H + Fe – ''Flavobacterium'' <br />
**[[6exf]] – FlL4H + Fe + lysine <br />
**[[6exf]] – FlL4H + Fe + lysine <br />
**[[6euo]] – FlL4H + Fe + succinate derivative<br />
**[[6euo]] – FlL4H + Fe + succinate derivative<br />
Line 157: Line 155:
*Lysine 3-hydroxylase
*Lysine 3-hydroxylase
-
**[[6f2e]] – CaL3H – Catenulispora acidiphila <br />
+
**[[6f2e]] – CaL3H – ''Catenulispora acidiphila'' <br />
**[[6f2b]] – CaL3H + Fe + oxoglutarate <br />
**[[6f2b]] – CaL3H + Fe + oxoglutarate <br />
**[[6f2a]] – CaL3H + Fe + lysine <br />
**[[6f2a]] – CaL3H + Fe + lysine <br />
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**[[6bz5]] - PpSH <br />
**[[6bz5]] - PpSH <br />
**[[5evy]] - PpSH + FAD + salicilate <br />
**[[5evy]] - PpSH + FAD + salicilate <br />
-
**[[7c8z]] - SH + Fe2S2 + Fe - Ralstonia <br />
+
**[[7c8z]] - SH + Fe2S2 + Fe - ''Ralstonia'' <br />
*Dopamine b-hydroxylase (cofactor ascorbic acid)
*Dopamine b-hydroxylase (cofactor ascorbic acid)
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*Ectoine hydroxylase
*Ectoine hydroxylase
-
**[[4mhr]] - SaEH – Sphingopyxis alaskensis <br />
+
**[[4mhr]] - SaEH – ''Sphingopyxis alaskensis'' <br />
**[[4mhu]] - SaEH + Fe <br />
**[[4mhu]] - SaEH + Fe <br />
**[[4q5o]] - SaEH + Fe + 5-hydroxyectoine <br />
**[[4q5o]] - SaEH + Fe + 5-hydroxyectoine <br />
-
**[[4nmi]] - VsEH – Virgibacillus salexigens<br />
+
**[[4nmi]] - VsEH – ''Virgibacillus salexigens''<br />
**[[3emr]] - VsEH + Fe <br />
**[[3emr]] - VsEH + Fe <br />

Current revision

3D structures of hydroxylases

Updated on 16-July-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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