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1k8u

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(New page: 200px<br /> <applet load="1k8u" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k8u, resolution 1.15&Aring;" /> '''CRYSTAL STRUCTURE O...)
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[[Image:1k8u.gif|left|200px]]<br />
 
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<applet load="1k8u" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1k8u, resolution 1.15&Aring;" />
 
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'''CRYSTAL STRUCTURE OF CALCIUM-FREE (OR APO) HUMAN S100A6; CYS3MET MUTANT (SELENOMETHIONINE DERIVATIVE)'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF CALCIUM-FREE (OR APO) HUMAN S100A6; CYS3MET MUTANT (SELENOMETHIONINE DERIVATIVE)==
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S100A6 is a member of the S100 family of Ca(2+) binding proteins, which, have come to play an important role in the diagnosis of cancer due to, their overexpression in various tumor cells. We have determined the, crystal structures of human S100A6 in the Ca(2+)-free and Ca(2+)-bound, states to resolutions of 1.15 A and 1.44 A, respectively. Ca(2+) binding, is responsible for a dramatic change in the global shape and charge, distribution of the S100A6 dimer, leading to the exposure of two, symmetrically positioned target binding sites. The results are consistent, with S100A6, and most likely other S100 proteins, functioning as Ca(2+), sensors in a way analogous to the prototypical sensors calmodulin and, troponin C. The structures have important implications for our, understanding of target binding and cooperativity of Ca(2+) binding in the, S100 family.
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<StructureSection load='1k8u' size='340' side='right'caption='[[1k8u]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1k8u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K8U FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8u OCA], [https://pdbe.org/1k8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k8u RCSB], [https://www.ebi.ac.uk/pdbsum/1k8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k8u ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/S10A6_HUMAN S10A6_HUMAN] May function as calcium sensor and contribute to cellular calcium signaling (Potential). May function by interacting with other proteins and indirectly play a role in the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k8/1k8u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k8u ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1K8U is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1K8U OCA].
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*[[S100 proteins 3D structures|S100 proteins 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution., Otterbein LR, Kordowska J, Witte-Hoffmann C, Wang CL, Dominguez R, Structure. 2002 Apr;10(4):557-67. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11937060 11937060]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dominguez, R.]]
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[[Category: Dominguez R]]
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[[Category: Otterbein, L.R.]]
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[[Category: Otterbein LR]]
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[[Category: apo]]
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[[Category: cacy]]
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[[Category: calcium free]]
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[[Category: calcium regulatory protein]]
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[[Category: calcyclin]]
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[[Category: s100a6]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:48:27 2007''
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Current revision

CRYSTAL STRUCTURE OF CALCIUM-FREE (OR APO) HUMAN S100A6; CYS3MET MUTANT (SELENOMETHIONINE DERIVATIVE)

PDB ID 1k8u

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