7x6w

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'''Unreleased structure'''
 
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The entry 7x6w is ON HOLD until 2024-06-15
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==SFTSV 2 fold hexamer==
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<StructureSection load='7x6w' size='340' side='right'caption='[[7x6w]], [[Resolution|resolution]] 5.18&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7x6w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_fever_with_thrombocytopenia_syndrome_virus Severe fever with thrombocytopenia syndrome virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X6W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X6W FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.18&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x6w OCA], [https://pdbe.org/7x6w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x6w RCSB], [https://www.ebi.ac.uk/pdbsum/7x6w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x6w ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GP_SFTSV GP_SFTSV] Structural component of the virion that interacts with glycoprotein C (By similarity). It shields the hydrophobic fusion loops of the glycoprotein C, preventing premature fusion (By similarity). The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (By similarity). They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after clathrin-mediated endocytosis of the virion (By similarity). Plays a role in the packaging of ribonucleoproteins and polymerase during virus assembly (PubMed:29467349).[UniProtKB:P09613][UniProtKB:P21401][UniProtKB:R4V2Q5]<ref>PMID:29467349</ref> Structural component of the virion that interacts with glycoprotein N (By similarity). Acts as a class II fusion protein that is activated upon acidification and subsequent repositioning of the glycoprotein N (By similarity). The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (By similarity). They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after clathrin-mediated endocytosis of the virion (By similarity).[UniProtKB:P09613][UniProtKB:P21401][UniProtKB:R4V2Q5]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Severe fever with thrombocytopenia syndrome virus]]
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[[Category: Lou Z]]
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[[Category: Sun Z]]

Current revision

SFTSV 2 fold hexamer

PDB ID 7x6w

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