8sxm
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8sxm is ON HOLD until Paper Publication Authors: Rua, A.J., Alexandrescu, A.T. Description: NMR structure of the ZNF750 zinc finger domain, Z* [[Ca...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR structure of the ZNF750 zinc finger domain, Z*== | |
| - | + | <StructureSection load='8sxm' size='340' side='right'caption='[[8sxm]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8sxm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SXM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sxm OCA], [https://pdbe.org/8sxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sxm RCSB], [https://www.ebi.ac.uk/pdbsum/8sxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sxm ProSAT]</span></td></tr> |
| - | [[Category: Alexandrescu | + | </table> |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/ZN750_HUMAN ZN750_HUMAN] Seborrhea-like dermatitis with psoriasiform elements. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ZN750_HUMAN ZN750_HUMAN] Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression.<ref>PMID:22364861</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Alexandrescu AT]] | ||
| + | [[Category: Rua AJ]] | ||
Current revision
NMR structure of the ZNF750 zinc finger domain, Z*
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