Insulin receptor 3D structures
From Proteopedia
(Difference between revisions)
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*Insulin receptor; domains: L1-CR 28-337; 1-3 28-512; transmembrane 940-988; TK 1005-1310; Ectodomain 28-1382 | *Insulin receptor; domains: L1-CR 28-337; 1-3 28-512; transmembrane 940-988; TK 1005-1310; Ectodomain 28-1382 | ||
| - | **[[1irk]] – hIR TK domain | + | **[[8u4b]] – hIR – human – Cryo EM<br /> |
| - | **[[1i44]], [[1p14]] – hIR TK domain (mutant) <br /> | + | **[[1irk]] – hIR TK domain <br /> |
| + | **[[1i44]], [[1p14]], [[8dwn]] – hIR TK domain (mutant) <br /> | ||
**[[2hr7]] – hIR domains 1-3<br /> | **[[2hr7]] – hIR domains 1-3<br /> | ||
**[[4xst]] – hIR L1-CR domains <br /> | **[[4xst]] – hIR L1-CR domains <br /> | ||
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**[[3bu5]], [[3bu6]] - hIR TK domain + ATP + peptide<br /> | **[[3bu5]], [[3bu6]] - hIR TK domain + ATP + peptide<br /> | ||
**[[3bu3]] - hIR TK domain + peptide<br /> | **[[3bu3]] - hIR TK domain + peptide<br /> | ||
| + | **[[8dtl]], [[8dtm]] - hIR ectodomain + peptide – Cryo EM<br /> | ||
**[[1gag]], [[2z8c]] - hIR TK domain (mutant) + peptide<br /> | **[[1gag]], [[2z8c]] - hIR TK domain (mutant) + peptide<br /> | ||
**[[3ekk]], [[3ekn]], [[4ibm]], [[5hhw]] - hIR TK domain (mutant) + inhibitor<br /> | **[[3ekk]], [[3ekn]], [[4ibm]], [[5hhw]] - hIR TK domain (mutant) + inhibitor<br /> | ||
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**[[2b4s]] - hIR TK domain + tyrosine-protein phosphatase<br /> | **[[2b4s]] - hIR TK domain + tyrosine-protein phosphatase<br /> | ||
**[[1rqq]] – hIR TK domain (mutant) + adaptor protein PS<br /> | **[[1rqq]] – hIR TK domain (mutant) + adaptor protein PS<br /> | ||
| - | **[[6ce7]], [[6ce9]], [[6ceb]] – hIR + insulin | + | **[[6ce7]], [[6ce9]], [[6ceb]] – hIR + insulin <br /> |
| - | **[[6pxv]], [[6pxw]], [[6sof]], [[7bw7]], [[7bw8]], [[7bwa]], [[7md4]], [[7md5]], [[7mqo]], [[7mqr]], [[7mqs]], [[7qid]], [[8guy]] – hIR ectodomain + insulin – Cryo EM<br /> | + | **[[6pxv]], [[6pxw]], [[6sof]], [[7bw7]], [[7bw8]], [[7bwa]], [[7md4]], [[7md5]], [[7mqo]], [[7mqr]], [[7mqs]], [[7qid]], [[8guy]], [[8yyl]], [[8yys]], [[8yyt]] – hIR ectodomain + insulin – Cryo EM<br /> |
| + | **[[8eyx]] – hIR ectodomain (mutant) + insulin – Cryo EM<br /> | ||
**[[7u6d]], [[7u6e]] – hIR ectodomain + agonist – Cryo EM<br /> | **[[7u6d]], [[7u6e]] – hIR ectodomain + agonist – Cryo EM<br /> | ||
**[[7yq3]], [[7yq4]], [[7yq5]], [[7yq6]] – hIR ectodomain + DNA – Cryo EM<br /> | **[[7yq3]], [[7yq4]], [[7yq5]], [[7yq6]] – hIR ectodomain + DNA – Cryo EM<br /> | ||
| + | **[[9jf9]], [[9jfd]], [[9jhs]] – hIR 28-946 + DNA – Cryo EM<br /> | ||
**[[7pg0]], [[7pg2]], [[7pg3]], [[7pg4]], [[7sl1]], [[7sl2]], [[7sl3]], [[7sl4]], [[7sl6]], [[7sl7]], [[7sth]], [[7sti]], [[7stj]], [[7stk]] – hIR + insulin – Cryo EM<br /> | **[[7pg0]], [[7pg2]], [[7pg3]], [[7pg4]], [[7sl1]], [[7sl2]], [[7sl3]], [[7sl4]], [[7sl6]], [[7sl7]], [[7sth]], [[7sti]], [[7stj]], [[7stk]] – hIR + insulin – Cryo EM<br /> | ||
**[[8dtl]], [[8dtm]] – hIR + insulin mimetic – Cryo EM<br /> | **[[8dtl]], [[8dtm]] – hIR + insulin mimetic – Cryo EM<br /> | ||
**[[7s8v]] – hIR ectodomain + IGF-I receptor – Cryo EM<br /> | **[[7s8v]] – hIR ectodomain + IGF-I receptor – Cryo EM<br /> | ||
| + | **[[8x06]], [[8x2m]], [[8xjs]], [[8xk1]], [[8xkm]], [[8xkr]] – hIR ectodomain + IGF-I – Cryo EM<br /> | ||
| + | **[[8u4c]], [[8u4e]], [[8vjc]], [[8ysz]] – hIR ectodomain + IGF-2 – Cryo EM<br /> | ||
**[[7s0q]] – hIR ectodomain + IGF-I receptor + IGF-I – Cryo EM<br /> | **[[7s0q]] – hIR ectodomain + IGF-I receptor + IGF-I – Cryo EM<br /> | ||
**[[6hn4]], [[6hn5]] - hIR + insulin <br /> | **[[6hn4]], [[6hn5]] - hIR + insulin <br /> | ||
Current revision
3D structures of insulin receptor
Updated on 22-September-2025
