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Ion channels 3D structures

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Current revision (08:57, 5 May 2024) (edit) (undo)
 
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Line 71: Line 71:
*Sodium channel; Domains – extracellular 30-157
*Sodium channel; Domains – extracellular 30-157
 +
**[[7dtd]] - hNaV 1.1 + hNav beta 4 – Cryo EM<br />
 +
**[[6agf]] - hNaV 1 + hNav 1.4 – Cryo EM<br />
**[[2kav]], [[2kbi]] – hNaV 1.2 C-terminal EF-hand domain – NMR<br />
**[[2kav]], [[2kbi]] – hNaV 1.2 C-terminal EF-hand domain – NMR<br />
 +
**[[7w77]], [[7w7f]] – hNaV 1.3 beta1+beta2 + hNaV type 3 subunit alpha – Cryo EM<br />
**[[5fdy]], [[5feb]] - hNaV 2 extracellular domain (mutant)<br />
**[[5fdy]], [[5feb]] - hNaV 2 extracellular domain (mutant)<br />
**[[6vrr]] - hNaV 2 (mutant)<br />
**[[6vrr]] - hNaV 2 (mutant)<br />
Line 77: Line 80:
**[[4mz2]] - hNaV 4 extracellular domain <br />
**[[4mz2]] - hNaV 4 extracellular domain <br />
**[[4mz3]], [[6vsv]] - hNaV 4 extracellular domain (mutant)<br />
**[[4mz3]], [[6vsv]] - hNaV 4 extracellular domain (mutant)<br />
-
**[[6bqn]] – hENaC ++g subunits – Cryo EM<br />
+
**[[6bqn]] – hENaC alpha+beta+gamma subunits – Cryo EM<br />
**[[7dtc]] – hNaV 1.5 (mutant) – Cryo EM<br />
**[[7dtc]] – hNaV 1.5 (mutant) – Cryo EM<br />
**[[7l83]] – hNaV 1.5 1597-1633 - NMR <br />
**[[7l83]] – hNaV 1.5 1597-1633 - NMR <br />
**[[8fhd]] – hNaV 1.6 – Cryo EM<br />
**[[8fhd]] – hNaV 1.6 – Cryo EM<br />
 +
**[[8gz1]] – hNaV 1.6 beta1+beta2 + hNaV type 8 subunit alpha – Cryo EM<br />
**[[7xvf]] – hNaV 1.7 (mutant) – Cryo EM<br />
**[[7xvf]] – hNaV 1.7 (mutant) – Cryo EM<br />
 +
**[[7w9l]], [[7w9t]] – hNaV 1.7 (mutant) + beta-1 + beta-2 – Cryo EM<br />
 +
**[[7w9k]] – hNaV 1.7 beta-1 + beta-2 – Cryo EM<br />
**[[7wfw]] – hNaV 1.8 – Cryo EM<br />
**[[7wfw]] – hNaV 1.8 – Cryo EM<br />
**[[7tj8]] – hNaV type 7 alpha – Cryo EM<br />
**[[7tj8]] – hNaV type 7 alpha – Cryo EM<br />
 +
**[[7tj9]] – hNaV type 7 alpha + beta-3 – Cryo EM<br />
**[[1byy]] – rNaCh IIA inactivation fragment<br />
**[[1byy]] – rNaCh IIA inactivation fragment<br />
**[[5jr0]] – rNaV 1.4 <br />
**[[5jr0]] – rNaV 1.4 <br />
Line 90: Line 97:
**[[1qg9]] – raNaCh IIA second repeat – NMR<br />
**[[1qg9]] – raNaCh IIA second repeat – NMR<br />
**[[5ayq]], [[5xax]], [[5xaw]] - mNaV 4 residues 30-160 <br />
**[[5ayq]], [[5xax]], [[5xaw]] - mNaV 4 residues 30-160 <br />
 +
**[[5xsy]] – eeNaV 1.4 + beta 1 – electric eel - Cryo EM <br />
**[[5x0m]] – coNaCh - cockroach <br />
**[[5x0m]] – coNaCh - cockroach <br />
-
**[[4bgn]] – NaCh – Caldalkalibacillus thermarum – Cryo EM<br />
+
**[[4bgn]] – NaCh –'' Caldalkalibacillus thermarum'' – Cryo EM<br />
-
**[[4lto]], [[4ltp]], [[4ltq]], [[5hk7]] – AeNaCh pore + cytoplasmic domains – Alkalilimnicola ehrlichii <br />
+
**[[4lto]], [[4ltp]], [[4ltq]], [[5hk7]] – AeNaCh pore + cytoplasmic domains – ''Alkalilimnicola ehrlichii'' <br />
**[[4ltr]], [[5hkd]], [[5hk6]], [[5kj8]] – AeNaCh pore + cytoplasmic domains (mutant) <br />
**[[4ltr]], [[5hkd]], [[5hk6]], [[5kj8]] – AeNaCh pore + cytoplasmic domains (mutant) <br />
**[[5iwn]], [[7pgh]] – AeNaCh pore domain<br />
**[[5iwn]], [[7pgh]] – AeNaCh pore domain<br />
Line 99: Line 107:
*Sodium channel complex
*Sodium channel complex
-
**[[7dtd]] - hNaV 1.1 + hNav b 4 – Cryo EM<br />
 
-
**[[6agf]] - hNaV 1 + hNav 1.4 – Cryo EM<br />
 
**[[6j8e]] - hNaV 2 + hNav 1.2 + Mu-conotoxin – Cryo EM<br />
**[[6j8e]] - hNaV 2 + hNav 1.2 + Mu-conotoxin – Cryo EM<br />
**[[6j8g]], [[6j8h]], [[6j8i]], [[6j8j]] - hNaV 2 + hNaV 1 + hNav 1.7 + toxin – Cryo EM<br />
**[[6j8g]], [[6j8h]], [[6j8i]], [[6j8j]] - hNaV 2 + hNaV 1 + hNav 1.7 + toxin – Cryo EM<br />
**[[6mba]], [[6mc9]] – hNaV 1.4 C terminal + calmodulin <br />
**[[6mba]], [[6mc9]] – hNaV 1.4 C terminal + calmodulin <br />
-
**[[6wth]] – hENaC ++g subunits + antibody – Cryo EM<br />
+
**[[6wth]] – hENaC alpha+beta+gamma subunits + antibody – Cryo EM<br />
-
**[[7w77]], [[7w7f]] – hNaV 1.3 beta1+beta2 + hNaV type 3 subunit alpha – Cryo EM<br />
+
**[[6lqa]] – hNaV 1.5 + quinidine - Cryo EM<br />
**[[6lqa]] – hNaV 1.5 + quinidine - Cryo EM<br />
**[[4ovn]], [[5dbr]], [[4djc]], [[6mud]] – hNaV 1.5 C terminal + calmodulin <br />
**[[4ovn]], [[5dbr]], [[4djc]], [[6mud]] – hNaV 1.5 C terminal + calmodulin <br />
**[[4dck]], [[4jq0]] – hNaV 1.5 C terminal + calmodulin + fibroblast growth factor <br />
**[[4dck]], [[4jq0]] – hNaV 1.5 C terminal + calmodulin + fibroblast growth factor <br />
**[[4jpz]] – hNaV 1.2 C terminal + calmodulin + fibroblast growth factor 13<br />
**[[4jpz]] – hNaV 1.2 C terminal + calmodulin + fibroblast growth factor 13<br />
-
**[[8gz1]] – hNaV 1.6 beta1+beta2 + hNaV type 8 subunit alpha – Cryo EM<br />
 
**[[8gz2]] – hNaV 1.6 beta1+beta2 + hNaV type 8 subunit alpha + toxin – Cryo EM<br />
**[[8gz2]] – hNaV 1.6 beta1+beta2 + hNaV type 8 subunit alpha + toxin – Cryo EM<br />
-
**[[7w9l]], [[7w9t]] – hNaV 1.7 (mutant) + beta-1 + beta-2 – Cryo EM<br />
 
-
**[[7w9k]] – hNaV 1.7 beta-1 + beta-2 – Cryo EM<br />
 
**[[7w9m]], [[7w9p]] – hNaV 1.7 beta1+beta2 + hNaV type 9 subunit alpha + toxin – Cryo EM<br />
**[[7w9m]], [[7w9p]] – hNaV 1.7 beta1+beta2 + hNaV type 9 subunit alpha + toxin – Cryo EM<br />
**[[7xm9]], [[7xmf]], [[7xmg]] – hNaV 1.7 beta1+beta2 + hNaV type 9 subunit alpha + inhibitor – Cryo EM<br />
**[[7xm9]], [[7xmf]], [[7xmg]] – hNaV 1.7 beta1+beta2 + hNaV type 9 subunit alpha + inhibitor – Cryo EM<br />
**[[7we4]], [[7wel]], [[7wfr]] – hNaV 1.8 + inhibitor – Cryo EM<br />
**[[7we4]], [[7wel]], [[7wfr]] – hNaV 1.8 + inhibitor – Cryo EM<br />
-
**[[7tj9]] – hNaV type 7 alpha + beta-3 – Cryo EM<br />
 
**[[6mue]] – raNaV 1.4 + calmodulin <br />
**[[6mue]] – raNaV 1.4 + calmodulin <br />
**[[6uz0]] – raNaV 5 + flecainide - Cryo EM<br />
**[[6uz0]] – raNaV 5 + flecainide - Cryo EM<br />
**[[7k18]] – raNaV 5 + toxin - Cryo EM<br />
**[[7k18]] – raNaV 5 + toxin - Cryo EM<br />
-
**[[5xsy]] – eeNaV 1.4 + b 1 – electric eel - Cryo EM <br />
 
**[[6a90]], [[6a91]], [[6a95]] – coNaCh + toxin – Cryo EM <br />
**[[6a90]], [[6a91]], [[6a95]] – coNaCh + toxin – Cryo EM <br />
**[[7pg8]], [[7pgb]] – AeNaCh pore + antibody<br />
**[[7pg8]], [[7pgb]] – AeNaCh pore + antibody<br />
 +
*Sodium channel, pre-activated. NavAb
*Sodium channel, pre-activated. NavAb
Line 163: Line 164:
**[[6lyp]], [[6vxm]], [[6vxn]], [[6vxp]] – AtMsc-like (mutant) – Cryo EM<br />
**[[6lyp]], [[6vxm]], [[6vxn]], [[6vxp]] – AtMsc-like (mutant) – Cryo EM<br />
-
* Chloride channel or H(+)/Cl(-) exchange transporter ClcA or human proton-activated chloride channel PAC
+
* Chloride channel or H(+)/Cl(-) exchange transporter ClcA or human proton-activated chloride channel PAC or CLIC
**[[1rk4]], [[3swl]] - hClCh protein 1<br />
**[[1rk4]], [[3swl]] - hClCh protein 1<br />
Line 203: Line 204:
**[[2jk4]], [[2k4t]], [[5jdp]], [[5xdo]], [[5xdn]], [[6g73]], [[6g6u]] – hVDAC1<br />
**[[2jk4]], [[2k4t]], [[5jdp]], [[5xdo]], [[5xdn]], [[6g73]], [[6g6u]] – hVDAC1<br />
**[[6tiq]] – hVDAC1 – NMR<br />
**[[6tiq]] – hVDAC1 – NMR<br />
 +
**[[7qi2]] – hVDAC1 (mutant) – NMR<br />
**[[6tir]] – hVDAC1 + NAD – NMR<br />
**[[6tir]] – hVDAC1 + NAD – NMR<br />
-
**[[6djb]], [[5zsu]] – hVDAC1 subunit LRRC8A – Cryo EM<br />
+
**[[6djb]], [[5zsu]], [[7xzh]] – hVDAC1 subunit LRRC8A – Cryo EM<br />
 +
**[[8dxn]], [[8dxo]], [[8dxp]], [[8dxq]], [[8dxr]] – hVDAC1 subunit LRRC8A + LRRC8C – Cryo EM<br />
**[[6m04]] – hVDAC1 subunit LRRC8AD (mutant) – Cryo EM<br />
**[[6m04]] – hVDAC1 subunit LRRC8AD (mutant) – Cryo EM<br />
 +
[[3emn]], [[4c69]] – mVDAC1 <br />
**[[7kuh]] – mVDAC – electron crystallography <br />
**[[7kuh]] – mVDAC – electron crystallography <br />
-
**[[3emn]], [[4c69]] – mVDAC1 <br />
 
**[[6g9o]], [[6g9l]], [[6g8z]], [[6o00]], [[6nzz]], [[6nzw]], [[7m17]], [[7m19]] – mVDAC1 subunit LRRC8A – Cryo EM<br />
**[[6g9o]], [[6g9l]], [[6g8z]], [[6o00]], [[6nzz]], [[6nzw]], [[7m17]], [[7m19]] – mVDAC1 subunit LRRC8A – Cryo EM<br />
 +
**[[8b40]] – mVDAC1 subunit LRRC8C – Cryo EM<br />
 +
**[[8ben]] – mVDAC1 subunit LRRC8C LRR domain – Cryo EM<br />
 +
**[[8b42]], [[8dr8]], [[8dra]], [[8dre]], [[8drk]], [[8drn]], [[8dro]], [[8drq]], [[8ds3]], [[8ds9]], [[8dsa]], [[8dxn]] – mVDAC1 subunit LRRC8A + LRRC8C – Cryo EM<br />
 +
**[[8f74]], [[8f75]], [[8f77]], [[8f79]], [[8f7b]], [[8f7d]], [[8f7e]], [[8f7j]] – mVDAC1 subunit LRRC8A + LRRC8C (mutant) – Cryo EM<br />
 +
**[[8b41]] – mVDAC1 subunit LRRC8A + LRRC8C + nanobody – Cryo EM<br />
**[[7p5v]], [[7p5w]], [[7p5y]], [[7p60]], [[7p6k]] – mVDAC1 subunit LRRC8A + nanobody – Cryo EM<br />
**[[7p5v]], [[7p5w]], [[7p5y]], [[7p60]], [[7p6k]] – mVDAC1 subunit LRRC8A + nanobody – Cryo EM<br />
**[[6fnw]] – mVDAC1 subunit LRRC8A C terminal<br />
**[[6fnw]] – mVDAC1 subunit LRRC8A C terminal<br />
-
**[[4bum]] – zeVDAC2 – zebra fish<br />
+
**[[4bum]] – zeVDAC2 <br />
**[[7en0]] – VDAC1 – ''Brachypodium distachyon'' – Cryo EM<br />
**[[7en0]] – VDAC1 – ''Brachypodium distachyon'' – Cryo EM<br />
 +
**[[7w6k]] – ALMT – soy bean – Cryo EM<br />
 +
**[[7wnq]] – AtSLAC1 – Cryo EM<br />
* Ligand-gated ion channel
* Ligand-gated ion channel
-
**[[2vl0]], [[2yn6]], [[3rqu]] – EchELIC – ''Erwinia chrysanthemi''<br />
+
**[[5osa]], [[5osb]] – mGLIC + GABAAR <br />
-
**[[2yks]], [[4twh]] - EchELIC (mutant)<br />
+
**[[5osc]] – mGLIC + GABAAR + drug<br />
 +
**[[2vl0]], [[3rqu]], [[2yn6]] – EchELIC –'' Erwinia chrysanthemi''<br />
 +
**[[2yks]], [[3uq4]], [[3uq5]], [[3uq7]], [[4twh]], [[5hej]], [[5heo]], [[5heu]], [[5hew]] – EchELIC (mutant)<br />
 +
**[[6v03]], [[6v0b]], [[8d63]], [[8d64]], [[8d65]] - EchELIC – Cryo EM<br />
 +
**[[8d66]], [[8d67]], [[8vuw]] – EchELIC3 (mutant) – Cryo EM<br />
**[[3rqw]] - EchELIC + acetylcholine<br />
**[[3rqw]] - EchELIC + acetylcholine<br />
 +
**[[5sxu]] - EchELIC + bromoethanol<br />
**[[4twd]], [[4twf]] - EchELIC (mutant) + memantine derivative<br />
**[[4twd]], [[4twf]] - EchELIC (mutant) + memantine derivative<br />
**[[3zkr]] - EchELIC + anesthetic<br />
**[[3zkr]] - EchELIC + anesthetic<br />
-
**[[4a97]], [[4a98]] – EchELIC + benzodiazepine<br />
+
**[[2yoe]] - EchELIC + drug + GABA<br />
-
**[[2yoe]] - EchELIC + flurazepam + GABA<br />
+
**[[4a97]], [[4a98]], [[5lid]], [[5lg3]] – EchELIC + drug<br />
-
**[[5lid]] – EchELIC + bromopromazine <br />
+
**[[5sxv]] – EchELIC + inhibitor <br />
**[[5sxv]] – EchELIC + inhibitor <br />
 +
**[[4yeu]] – EchELIC + GLIC <br />
 +
**[[6hk0]] – DcELIC (mutant) – Dickeya chrysanthemi<br />
 +
**[[6hjx]], [[6hjy]], [[6ssi]], [[6ssp]] – DcELIC + nanobody <br />
 +
**[[6fl9]], [[6fli]], [[6fvq]], [[6fvr]], [[6fvs]] - ELIC – vent tica<br />
 +
**[[3eam]], [[3ehz]], [[4hfi]], [[4il4]], [[4ilc]], [[4npp]], [[4npq]], [[4qh1]], [[4qh5]], [[4qh4]], [[6f7a]], [[6f16]], [[4zzc]], [[6hzw]] – GvGLIC - Gloeobacter violaceus<br />
 +
**[[6zgd]], [[6zgj]], [[6zgk]] – GvGLIC – Cryo EM<br />
**[[6hk0]] – DcELIC (mutant) – ''Dickeya chrysanthemi''<br />
**[[6hk0]] – DcELIC (mutant) – ''Dickeya chrysanthemi''<br />
**[[6hjx]], [[6hjy]], [[6ssi]], [[6ssp]] – DcELIC + nanobody <br />
**[[6hjx]], [[6hjy]], [[6ssi]], [[6ssp]] – DcELIC + nanobody <br />
Line 239: Line 259:
**[[5l47]], [[5l4e]], [[5l4h]] - GvGLIC + barbiturate<br />
**[[5l47]], [[5l4e]], [[5l4h]] - GvGLIC + barbiturate<br />
**[[6hj3]], [[6hjb]], [[6hji]], [[6hja]], [[6hjz]], [[6hpp]] - GvGLIC + carboxylate<br />
**[[6hj3]], [[6hjb]], [[6hji]], [[6hja]], [[6hjz]], [[6hpp]] - GvGLIC + carboxylate<br />
-
**[[6v03]], [[6v0b]] - ELIC – ''Dickeya dadantii'' – Cryo EM<br />
+
**[[6v4a]], [[6v4s]], [[7q3g]] - DeELIC – ''Desulfofustis''<br />
 +
**[[7q3h]] – DeELIC – Cryo EM<br />
* Cyclic Nucleotide-Gated channel
* Cyclic Nucleotide-Gated channel
Line 246: Line 267:
**[[7lft]] – hCNGA1 + cGMP – Cryo EM<br />
**[[7lft]] – hCNGA1 + cGMP – Cryo EM<br />
**[[7lfw]], [[7lfx]], [[7lfy]] – hCNGA1 (mutant) + cGMP – Cryo EM<br />
**[[7lfw]], [[7lfx]], [[7lfy]] – hCNGA1 (mutant) + cGMP – Cryo EM<br />
 +
**[[7rh9]], [[7rhl]] – hCNGA1 + CNGB1 – Cryo EM<br />
 +
**[[7rhg]], [[7rhh]], [[7rhi]], [[7rhj]], [[7rhk]] – hCNGA1 + CNGB1 + cGMP – Cryo EM<br />
 +
**[[8bx7]] – bCNGA1 + CNGB1 + cGMP – Cryo EM<br />
 +
**[[7rhs]] – hCNGA3 + CNGB3 – Cryo EM<br />
**[[3swf]] - bCNGC CLZ domain <br />
**[[3swf]] - bCNGC CLZ domain <br />
**[[2zd9]], [[3beh]] - MlCNGC - ''Mesorhizobium loti''<br />
**[[2zd9]], [[3beh]] - MlCNGC - ''Mesorhizobium loti''<br />
Line 286: Line 311:
**[[7rnn]] – hASC + nanobody – Cryo EM<br />
**[[7rnn]] – hASC + nanobody – Cryo EM<br />
**[[3ij4]], [[2qts]], [[3s3w]], [[4nyk]], [[3ij4]], [[6ave]], [[5wku]], [[5wkv]], [[5wky]], [[5wkx]], [[6cmc]] – cASC – chicken<br />
**[[3ij4]], [[2qts]], [[3s3w]], [[4nyk]], [[3ij4]], [[6ave]], [[5wku]], [[5wkv]], [[5wky]], [[5wkx]], [[6cmc]] – cASC – chicken<br />
 +
**[[7lie]] – cASC thumb domain 291-367<br />
**[[6vtk]], [[6vtl]] – cASC – Cryo EM<br />
**[[6vtk]], [[6vtl]] – cASC – Cryo EM<br />
**[[3s3x]], [[4fz0]], [[4fz1]] – cASC + psalmotoxin<br />
**[[3s3x]], [[4fz0]], [[4fz1]] – cASC + psalmotoxin<br />
Line 291: Line 317:
**[[6x9h]] – cASC + modulator<br />
**[[6x9h]] – cASC + modulator<br />
-
* ATP-Gated P2X channel (AGC) or purinoceptor
+
* ATP-Gated P2X channel (AGC) or P2X purinoceptor
-
**[[5vj]], [[5svt]] – hAGC P2X3 <br />
+
**[[5svj]], [[5svs]], [[5svt]] – hAGC P2X3 <br />
**[[5yve]] – hAGC P2X3 + modulator<br />
**[[5yve]] – hAGC P2X3 + modulator<br />
**[[5svq]], [[5svr]] – hAGC P2X3 + antagonist<br />
**[[5svq]], [[5svr]] – hAGC P2X3 + antagonist<br />
**[[5svm]], [[5svp]] – hAGC P2X3 + agonist<br />
**[[5svm]], [[5svp]] – hAGC P2X3 + agonist<br />
**[[5svk]], [[5svl]], [[6ah4]], [[6ah5]] – hAGC P2X3 + ATP<br />
**[[5svk]], [[5svl]], [[6ah4]], [[6ah5]] – hAGC P2X3 + ATP<br />
 +
**[[5u1l]] – paAGC P2X - panda<br />
 +
**[[5u1u]], [[5u1v]], [[5u1w]], [[5u1x]], [[5u1y]] – paAGC P2X + antagonist <br />
 +
**[[5u2h]] – paAGC P2X + antagonist + ATP <br />
 +
**[[6u9v]] – raAGC P2X7 – Cryo EM<br />
 +
**[[6u9w]] – raAGC P2X7 + ATP – Cryo EM<br />
 +
**[[2rup]] – raAGC P2X4 head domain 111-167 – NMR<br />
**[[5xw6]] – cAGC P2X7 + antagonist<br />
**[[5xw6]] – cAGC P2X7 + antagonist<br />
**[[3h9v]], [[3i5d]] – zeAGC P2X4<br />
**[[3h9v]], [[3i5d]] – zeAGC P2X4<br />
**[[4dw0]] – zeAGC P2X4 (mutant)<br />
**[[4dw0]] – zeAGC P2X4 (mutant)<br />
**[[4dw1]] – zeAGC P2X4 + ATP<br />
**[[4dw1]] – zeAGC P2X4 + ATP<br />
 +
**[[5wzy]] – zeAGC P2X4 + CTP<br />
* Proton channel or matrix protein 2
* Proton channel or matrix protein 2
Line 311: Line 344:
**[[5c02]], [[4rwc]], [[4rwb]], [[2kih]], [[6mjh]] - IVproton channel transmembrane domain (mutant)<br />
**[[5c02]], [[4rwc]], [[4rwb]], [[2kih]], [[6mjh]] - IVproton channel transmembrane domain (mutant)<br />
**[[2n70]] - IVproton channel transmembrane domain (mutant) - NMR<br />
**[[2n70]] - IVproton channel transmembrane domain (mutant) - NMR<br />
-
**[[6bkk]], [[6bkl]], [[6bmz]], [[6boc]] - IVproton channel transmembrane domain + drug<br />
+
**[[6bkk]], [[6bkl]], [[6bmz]], [[6boc]], [[6us8]], [[6us9]] - IVproton channel transmembrane domain + drug<br />
-
**[[2kqt]] - IVproton channel transmembrane domain + drug - NMR<br />
+
**[[2h95]], [[2kqt]] - IVproton channel transmembrane domain + drug - NMR<br />
**[[2ly0]] - IVproton channel transmembrane domain (mutant) + drug - NMR<br />
**[[2ly0]] - IVproton channel transmembrane domain (mutant) + drug - NMR<br />
**[[2rlf]] - IVproton channel + inhibitor - NMR<br />
**[[2rlf]] - IVproton channel + inhibitor - NMR<br />
**[[3c9j]], [[6oug]] - IVproton channel transmembrane domain + inhibitor<br />
**[[3c9j]], [[6oug]] - IVproton channel transmembrane domain + inhibitor<br />
**[[6nv1]] - IVproton channel transmembrane domain (mutant) + inhibitor<br />
**[[6nv1]] - IVproton channel transmembrane domain (mutant) + inhibitor<br />
 +
**[[8bdz]], [[8ber]] - proton channel M2 – Hepatitis virus – Cryo EM<br />
* Voltage-gated hydrogen channel (VGHC)
* Voltage-gated hydrogen channel (VGHC)
Line 330: Line 364:
*''TRPV1 or capsaicin receptor''
*''TRPV1 or capsaicin receptor''
 +
**[[7lp9]], [[7lpa]], [[7lpc]], [[7lpd]], [[8gf8]], [[8gf9]], [[8gfa]] – hTRPV1 – Cryo EM<br />
 +
**[[6l93]] – hTRPV1 ankyrin repeat domain 101-365<br />
 +
**[[2nyj]] – hTRPV1 ankyrin repeat domain + ATP<br />
**[[7lqy]], [[7lqz]] – sTRPV1 – squirrel - Cryo EM<br />
**[[7lqy]], [[7lqz]] – sTRPV1 – squirrel - Cryo EM<br />
**[[7lr0]] – sTRPV1 + capsaicin - Cryo EM<br />
**[[7lr0]] – sTRPV1 + capsaicin - Cryo EM<br />
-
**[[6l93]] – hTRPV1 ankyrin repeat domain 101-365<br />
 
**[[3j5p]], [[3j5r]], [[3j9j]], [[5irz]] – rTRPV1 – Cryo EM<br />
**[[3j5p]], [[3j5r]], [[3j9j]], [[5irz]] – rTRPV1 – Cryo EM<br />
**[[5is0]] – rTRPV1+ capsaicin derivative – Cryo EM<br />
**[[5is0]] – rTRPV1+ capsaicin derivative – Cryo EM<br />
Line 338: Line 374:
**[[3j5q]] – rTRPV1+ toxin – Cryo EM<br />
**[[3j5q]] – rTRPV1+ toxin – Cryo EM<br />
**[[2pnn]] – rTRPV1 ankyrin repeat domain <br />
**[[2pnn]] – rTRPV1 ankyrin repeat domain <br />
-
**[[2nyj]] – hTRPV1 ankyrin repeat domain + ATP<br />
+
**[[7l2h]], [[7l2i]], [[7l2j]], [[7l2k]], [[7l2l]], [[7l2m]], [[7l2n]], [[7l2o]], [[7l2p]], [[7l2r]], [[7l2s]], [[7l2t]], [[7l2u]], [[7l2v]], [[7l2w]], [[7l2x]], [[7lpb]], [[7lpe]], [[7mz5]], [[7mz6]], [[7mz7]], [[7mz9]], [[7mza]], [[7mzb]], [[7mzc]], [[7mzd]], [[7mze]], [[7rqu]], [[7rqv]], [[7rqw]], [[7rqx]], [[7rqy]], [[7rqz]] – raTRPV1 + drug – Cryo EM<br />
*''TRPV2''
*''TRPV2''
Line 346: Line 382:
**[[2eta]], [[2etb]], [[2etc]] – rTRPV2 ankyrin repeat domain - rat<br />
**[[2eta]], [[2etb]], [[2etc]] – rTRPV2 ankyrin repeat domain - rat<br />
**[[6bo4]], [[6bo5]], [[6u84]], [[6u86]] – rTRPV2 – Cryo EM<br />
**[[6bo4]], [[6bo5]], [[6u84]], [[6u86]] – rTRPV2 – Cryo EM<br />
 +
**[[6wkn]], [[7n0m]], [[7n0n]], [[7t37]], [[7t38]], [[7zjh]], [[8slx]], [[8sly]] – raTRPV2 + cannabidiol – Cryo EM<br />
**[[6u88]], [[6u8a]] – rTRPV2 + cannabidiol – Cryo EM<br />
**[[6u88]], [[6u8a]] – rTRPV2 + cannabidiol – Cryo EM<br />
**[[6bwm]] – raTRPV2 – rabbit<br />
**[[6bwm]] – raTRPV2 – rabbit<br />
Line 351: Line 388:
**[[6bwj]] – raTRPV2 (mutant) + resiniferatoxin<br />
**[[6bwj]] – raTRPV2 (mutant) + resiniferatoxin<br />
**[[6b5v]] – raTRPV2 + inhibitor – Cryo EM<br />
**[[6b5v]] – raTRPV2 + inhibitor – Cryo EM<br />
 +
**[[7xeu]] – mTRPV2 – Cryo EM<br />
 +
**[[7xer]], [[7xew]] – mTRPV2 (mutant) – Cryo EM<br />
 +
**[[7xem]] – mTRPV2 + cholesterol – Cryo EM<br />
 +
**[[7xeo]], [[7xev]], [[7yep]] – mTRPV2 + ligand – Cryo EM<br />
*''TRPV3''
*''TRPV3''
Line 357: Line 398:
**[[6ot2]], [[6uw6]], [[6uw8]], [[6uw9]] – hTRPV3 (mutant) – Cryo EM<br />
**[[6ot2]], [[6uw6]], [[6uw8]], [[6uw9]] – hTRPV3 (mutant) – Cryo EM<br />
**[[6ot5]] – hTRPV3 (mutant) + inhibitor – Cryo EM<br />
**[[6ot5]] – hTRPV3 (mutant) + inhibitor – Cryo EM<br />
-
**[[6dvw]], [[6dvy]], [[6lgp]], [[6pvl]], [[6pvm]] – mTRPV3 – Cryo EM<br />
+
**[[7xj0]] – hTRPV3 + drug – Cryo EM<br />
 +
**[[6dvw]], [[6dvy]], [[6lgp]], [[6pvl]], [[6pvm]], [[7mik]] – mTRPV3 – Cryo EM<br />
 +
**[[7mij]], [[7mik]], [[7mil]], [[7mim]], [[7min]], [[7mio]], [[7ras]], [[7rau]], [[7ugg]] – mTRPV3 + drug – Cryo EM<br />
**[[6dvz]], [[6pvn]], [[6pvp]], [[6pvo]], [[6pvq]] – mTRPV3 (mutant) – Cryo EM<br />
**[[6dvz]], [[6pvn]], [[6pvp]], [[6pvo]], [[6pvq]] – mTRPV3 (mutant) – Cryo EM<br />
**[[4n5q]] – mTRPV3 ankyrin repeat domain 118-367<br />
**[[4n5q]] – mTRPV3 ankyrin repeat domain 118-367<br />
Line 363: Line 406:
*''TRPV4''
*''TRPV4''
 +
**[[7aa5]] – hTRPV4 + agonist – Cryo EM<br />
 +
**[[4dx1]], [[4dx2]] – hTRPV4 ankyrin repeat domain 149-397<br />
**[[6c8f]], [[6c8g]], [[6c8h]] – fTRPV4 (mutant) – frog<br />
**[[6c8f]], [[6c8g]], [[6c8h]] – fTRPV4 (mutant) – frog<br />
**[[6bbj]] – fTRPV4 – Cryo EM<br />
**[[6bbj]] – fTRPV4 – Cryo EM<br />
Line 371: Line 416:
**[[5oeo]] – hTRPV5 655-725 + calmodulin – NMR<br />
**[[5oeo]] – hTRPV5 655-725 + calmodulin – NMR<br />
-
**[[6dmr]], [[6dmu]], [[6o1n]], [[6o1p]], [[6pbe]], [[6pbf]] – raTRPV5 – Cryo EM<br />
+
**[[6dmr]], [[6dmu]], [[6o1n]], [[6o1p]], [[6pbe]], [[6pbf]], [[7t6j]], [[7t6k]], [[7t6l]], [[7t6m]], [[7t6n]], [[7t6o]] – rTRPV5 – Cryo EM<br />
-
**[[6o1u]] – raTRPV5 (mutant) – Cryo EM<br />
+
**[[6o1u]], [[7t6p]], [[7t6q]], [[7t6r]] – rTRPV5 (mutant) – Cryo EM<br />
**[[6dmw]], [[6o20]] – raTRPV5 + calmodulin – Cryo EM<br />
**[[6dmw]], [[6o20]] – raTRPV5 + calmodulin – Cryo EM<br />
*''TRPV6''
*''TRPV6''
-
**[[6bo8]], [[6bo9]] – hTRPV6 – Cryo EM<br />
+
**[[6bo8]], [[6bo9]], [[7k4a]], [[8fob]] – hTRPV6 – Cryo EM<br />
**[[6boa]], [[6d7s]], [[6d7t]] – hTRPV6 (mutant) – Cryo EM<br />
**[[6boa]], [[6d7s]], [[6d7t]] – hTRPV6 (mutant) – Cryo EM<br />
 +
**[[7k4b]], [[7k4c]], [[7k4d]], [[7k4e]], [[7k4f]], [[7s8c]], [[8foa]] – hTRPV6 + inhibitor – Cryo EM<br />
 +
**[[7s88]], [[7s89]], [[7s8b]] – hTRPV6 + blocker – Cryo EM<br />
**[[5iwk]], [[5iwp]], [[5iwr]], [[5iwt]], [[5wo6]], [[5wo7]], [[5wo8]], [[5wo9]], [[5woa]], [[6d7o]], [[6d7v]] – rTRPV6<br />
**[[5iwk]], [[5iwp]], [[5iwr]], [[5iwt]], [[5wo6]], [[5wo7]], [[5wo8]], [[5wo9]], [[5woa]], [[6d7o]], [[6d7v]] – rTRPV6<br />
**[[6d7p]], [[6d7q]], [[6d7x]] – rTRPV6 (mutant) <br />
**[[6d7p]], [[6d7q]], [[6d7x]] – rTRPV6 (mutant) <br />
Line 384: Line 431:
**[[6e2f]], [[6e2g]] – rTRPV6 + calmodulin – Cryo EM<br />
**[[6e2f]], [[6e2g]] – rTRPV6 + calmodulin – Cryo EM<br />
**[[2rfa]] – mTRPV6 ankyrin repeat domain 44-265<br />
**[[2rfa]] – mTRPV6 ankyrin repeat domain 44-265<br />
 +
**[[7d2k]] – raTRPV6 + inhibitor – Cryo EM<br />
*Glycerol facilitator
*Glycerol facilitator

Current revision

3D structures of ion channels

Updated on 05-May-2024


3emn, 4c69 – mVDAC1

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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