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8t0z
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human liver-type glutaminase (K253A) with L-Gln, filamentous form== | |
| - | + | <StructureSection load='8t0z' size='340' side='right'caption='[[8t0z]], [[Resolution|resolution]] 3.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8t0z]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8T0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8T0Z FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLN:GLUTAMINE'>GLN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8t0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8t0z OCA], [https://pdbe.org/8t0z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8t0z RCSB], [https://www.ebi.ac.uk/pdbsum/8t0z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8t0z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GLSL_HUMAN GLSL_HUMAN] Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.<ref>PMID:20378837</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Aplin C]] | ||
| + | [[Category: Cerione RA]] | ||
| + | [[Category: Feng S]] | ||
| + | [[Category: Milano SK]] | ||
| + | [[Category: Nguyen T-TT]] | ||
Current revision
Human liver-type glutaminase (K253A) with L-Gln, filamentous form
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