1kzz

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[[Image:1kzz.jpg|left|200px]]
 
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==DOWNSTREAM REGULATOR TANK BINDS TO THE CD40 RECOGNITION SITE ON TRAF3==
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The line below this paragraph, containing "STRUCTURE_1kzz", creates the "Structure Box" on the page.
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<StructureSection load='1kzz' size='340' side='right'caption='[[1kzz]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kzz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KZZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kzz OCA], [https://pdbe.org/1kzz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kzz RCSB], [https://www.ebi.ac.uk/pdbsum/1kzz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kzz ProSAT]</span></td></tr>
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{{STRUCTURE_1kzz| PDB=1kzz | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TRAF3_HUMAN TRAF3_HUMAN] Defects in TRAF3 are the cause of susceptibility to herpes simplex encephalitis 3 (HSE3) [MIM:[https://omim.org/entry/614849 614849]. A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.<ref>PMID:20832341</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/TRAF3_HUMAN TRAF3_HUMAN] Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.<ref>PMID:15383523</ref> <ref>PMID:15084608</ref> <ref>PMID:17991829</ref> <ref>PMID:20097753</ref> <ref>PMID:20185819</ref> <ref>PMID:19937093</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/1kzz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kzz ConSurf].
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<div style="clear:both"></div>
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'''DOWNSTREAM REGULATOR TANK BINDS TO THE CD40 RECOGNITION SITE ON TRAF3'''
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==See Also==
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*[[TNF receptor-associated factor 3D structures|TNF receptor-associated factor 3D structures]]
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== References ==
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==Overview==
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<references/>
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TRAFs (tumor necrosis factor receptor [TNFR]-associated factors) bind to the cytoplasmic portion of liganded TNFRs and stimulate activation of NF-kappaB or JNK pathways. A modulator of TRAF signaling, TANK, serves as either an enhancer or an inhibitor of TRAF-mediated signaling pathways. The crystal structure of a region of TANK bound to TRAF3 has been determined and compared to a similar CD40/TRAF3 complex. TANK and CD40 bind to the same crevice on TRAF3. The recognition motif PxQxT is presented in a boomerang-like structure in TANK that is markedly different from the hairpin loop that forms in CD40 upon binding to TRAF3. Critical TANK contact residues were confirmed by mutagenesis to be required for binding to TRAF3 or TRAF2. Binding affinity, measured by isothermal titration calorimetry and competition assays, demonstrated that TANK competes with CD40 for the TRAF binding site.
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__TOC__
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</StructureSection>
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==About this Structure==
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1KZZ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZZ OCA].
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==Reference==
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Downstream regulator TANK binds to the CD40 recognition site on TRAF3., Li C, Ni CZ, Havert ML, Cabezas E, He J, Kaiser D, Reed JC, Satterthwait AC, Cheng G, Ely KR, Structure. 2002 Mar;10(3):403-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12005438 12005438]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Cabezas, E.]]
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[[Category: Cabezas E]]
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[[Category: Cheng, G.]]
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[[Category: Cheng G]]
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[[Category: Ely, K R.]]
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[[Category: Ely KR]]
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[[Category: Havert, M L.]]
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[[Category: Havert ML]]
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[[Category: He, J.]]
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[[Category: He J]]
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[[Category: Kaiser, D.]]
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[[Category: Kaiser D]]
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[[Category: Li, C.]]
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[[Category: Li C]]
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[[Category: Ni, C Z.]]
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[[Category: Ni C-Z]]
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[[Category: Reed, J C.]]
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[[Category: Reed JC]]
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[[Category: Satterthwait, A C.]]
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[[Category: Satterthwait AC]]
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[[Category: Cd40]]
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[[Category: Nf-kb signaling]]
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[[Category: Tank]]
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[[Category: Tnf receptor]]
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[[Category: Traf3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:23:05 2008''
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Current revision

DOWNSTREAM REGULATOR TANK BINDS TO THE CD40 RECOGNITION SITE ON TRAF3

PDB ID 1kzz

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