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Kinesin 3D Structures
From Proteopedia
(Difference between revisions)
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*KIF1A, KIF1B, KIF1C or kinesin-3 | *KIF1A, KIF1B, KIF1C or kinesin-3 | ||
| - | + | **[[1bg2]] – hKIF MD - human<br /> | |
| - | **[[1bg2]] – hKIF MD | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
**[[4hna]], [[4lnu]] – hKIF1 + Tubulin + designed ankyrin repeat protein + Mg-ADP + GDP + GTP + AlF4<br /> | **[[4hna]], [[4lnu]] – hKIF1 + Tubulin + designed ankyrin repeat protein + Mg-ADP + GDP + GTP + AlF4<br /> | ||
**[[4uxy]] – hKIF1 MD + Tubulin + GDP + GTP – Cryo EM<br /> | **[[4uxy]] – hKIF1 MD + Tubulin + GDP + GTP – Cryo EM<br /> | ||
| Line 22: | Line 17: | ||
**[[2wbe]] – bKIF MD+FNL+Tubulin +AMPPNP – bovine <br /> | **[[2wbe]] – bKIF MD+FNL+Tubulin +AMPPNP – bovine <br /> | ||
**[[3edl]] – bKIF MD+ Tubulin – EM<br /> | **[[3edl]] – bKIF MD+ Tubulin – EM<br /> | ||
| - | **[[3uyq]] – pKIF1A head+AMPPNP – pig<br /> | ||
| - | **[[2hxh]] - pKIF1A head+ADP<br /> | ||
| - | **[[2hxf]] - pKIF1A head+AMPPNP<br /> | ||
| - | **[[1ia0]] – pKIF1A MD+Tubulin +ATP <br /> | ||
| - | **[[2zfi]], [[2zfj]], [[2zfk]], [[2zfl]], [[2zfm]] – mKIF1A – mouse<br /> | ||
| - | **[[1vfv]], [[1vfw]] – mKIF1A MD+Mg-AMPPNP<br /> | ||
| - | **[[1vfx]] - mKIF1A MD+ADP-Mg-AlFx<br /> | ||
| - | **[[7eo9]], [[7eob]] - mKIF1A MD (mutant) +ADP-Mg-AlFx<br /> | ||
| - | **[[1vfz]] - mKIF1A MD+ADP-Mg-VO4<br /> | ||
**[[4atx]] - rKIF MD+ Tubulin – rat - Cryo EM<br /> | **[[4atx]] - rKIF MD+ Tubulin – rat - Cryo EM<br /> | ||
| - | **[[2owm]] – NcKIF1C MD – ''Neurospora crassa''<br /> | ||
| - | * | + | *KIF-like 1A, KIF-like 1B, KIF-like 1C |
| - | **[[ | + | **[[4ejq]], [[4egx]] – hKIFL 1A CC1-FHA domain 430-607<br /> |
| - | **[[2gry]] – | + | **[[5lt0]], [[5lt1]], [[5lt2]], [[5lt3]], [[5lt4]] – hKIFL 1 MD (mutant) <br /> |
| - | **[[6bbn]] – | + | **[[2g1l]] – hKIFL 1C FHA domain<br /> |
| - | **[[5mio]] – | + | **[[5wdh]] – hKIFL 1C MD<br /> |
| - | **[[1v8j]], [[5xja]], [[5xjb]] – | + | **[[2eh0]] – hKIFL 1B FHA domain – NMR<br /> |
| - | **[[1i5s]] | + | **[[2hxh]] – pKIFL 1A head+ADP - pig<br /> |
| - | **[[1i6i]] | + | **[[2hxf]] – pKIFL 1A head+AMPPNP<br /> |
| - | **[[1v8k]] | + | **[[1ia0]] – pKIFL 1A MD+Tubulin +ATP <br /> |
| + | **[[2zfi]], [[2zfj]], [[2zfk]], [[2zfl]], [[2zfm]] – mKIFL 1A – mouse<br /> | ||
| + | **[[1vfv]], [[1vfw]] – mKIFL 1A MD+Mg-AMPPNP<br /> | ||
| + | **[[1vfx]] – mKIFL 1A MD+ADP-Mg-AlFx<br /> | ||
| + | **[[7eo9]], [[7eob]] – mKIFL 1A MD (mutant) +ADP-Mg-AlFx<br /> | ||
| + | **[[1vfz]] – mKIFL 1A MD+ADP-Mg-VO4<br /> | ||
| + | **[[2owm]] – NcKIFL 1C MD – ''Neurospora crassa''<br /> | ||
| + | |||
| + | |||
| + | *KIF-like 2A, KIF-like 2C or kinesin-13 | ||
| + | |||
| + | **[[2heh]], [[4ubf]] – hKIFL 2C<br /> | ||
| + | **[[2gry]] – hKIFL 2+ADP<br /> | ||
| + | **[[6bbn]] – hKIFL 2A MD + Tubulin + Darpin<br /> | ||
| + | **[[5mio]] – hKIFL 2C MD + Tubulin <br /> | ||
| + | **[[1v8j]], [[5xja]], [[5xjb]] – mKIFL 2C MD+Mg-ADP<br /> | ||
| + | **[[1i5s]] – mKIFL 2C MD (mutant)+Mg-ADP<br /> | ||
| + | **[[1i6i]] – mKIFL 2C MD (mutant)+Mg-AMPPCP<br /> | ||
| + | **[[1v8k]] – mKIFL 2C MD+Mg-AMPPNP<br /> | ||
**[[2vvg]] – KIF2 MD – ''Giardia intestinalis''<br /> | **[[2vvg]] – KIF2 MD – ''Giardia intestinalis''<br /> | ||
| - | * | + | *KIF-like 3B, KIF-like 3C or kinesin-2 |
| - | **[[3b6u]], [[3b6v]] – | + | **[[3b6u]], [[3b6v]] – hKIFL 3B MD<br /> |
| - | **[[5wde]] – | + | **[[5wde]] – hKIFL 3C+ADP<br /> |
*KIF4A, KIF4B or kinesin-4 | *KIF4A, KIF4B or kinesin-4 | ||
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**[[3j6h]] – mKIF5C MD+Mg-GTP + G2P + tubulin <br /> | **[[3j6h]] – mKIF5C MD+Mg-GTP + G2P + tubulin <br /> | ||
**[[3j8x]], [[3j8y]] – mKIF5C MD+ GTP + GDP + tubulin<br /> | **[[3j8x]], [[3j8y]] – mKIF5C MD+ GTP + GDP + tubulin<br /> | ||
| + | **[[2y5w]], [[2y65]] - DmKIF MD – Drosophila melanogasgter<br /> | ||
| + | **[[4pxt]], [[4pxu]] – DmKIF MD (mutant)<br /> | ||
| + | **[[1n6m]] – DmKIF MD+FNL<br /> | ||
| + | **[[3l1c]] – DmNCD (mutant)<br /> | ||
| - | * | + | *KIF-like 7 or kinesin-4 |
| - | **[[4a14]] – | + | **[[4a14]] – hKIFL 7 MD <br /> |
| - | **[[2xt3]] – | + | **[[2xt3]] – hKIFL 7 MD (mutant)<br /> |
| - | **[[6mlr]] – | + | **[[6mlr]] – hKIFL 7 MD + Tubulin + GTP + GDP + ANP – Cryo EM<br /> |
| - | **[[6mlq]] – | + | **[[6mlq]] – hKIFL 7 MD + Tubulin + GTP + GDP + ADP – Cryo EM<br /> |
| - | **[[7rx0]] – | + | **[[7rx0]] – hKIFL 7 MD + GLI2 ANTubulin + GTP + GDP + G2P – Cryo EM<br /> |
| - | * | + | *KIF-like 9 or kinesin-9 |
| - | **[[3nwn]] – | + | **[[3nwn]] – hKIFL 9+ADP<br /> |
| - | * | + | *KIF-like 10A or kinesin-6 |
| - | **[[3j2u]] – | + | **[[3j2u]] – hKIFL 10A head domain – Cryo EM<br /> |
| - | **[[6b0c]], [[6b0l]] – | + | **[[6b0c]], [[6b0l]] – DmKIFL 10A + tubulin + GTP + GDP + ANP + Mg – Cryo EM<br /> |
| - | **[[6vpp]] – | + | **[[6vpp]] – DmKIFL 61F + tubulin + GTP + GDP + Mg – Cryo EM<br /> |
| - | **[[6vpo]] – | + | **[[6vpo]] – DmKIFL 61F + tubulin + GTP + GDP + ANP + Mg – Cryo EM<br /> |
| - | **[[6b0i]] – | + | **[[6b0i]] – DmKIFL 10A + tubulin + GTP + GDP + Mg – Cryo EM<br /> |
| - | * | + | *KIF-like 11 or kinesin-5 or Eg5 |
| - | **[[4b7b]] | + | **[[4b7b]] – hKIFL 11 (mutant) + ADP + Co + Cd <br /> |
| - | **[[3ken]], [[2wog]], [[2x2r]], [[2xae]], [[4bbg]] | + | **[[3ken]], [[2wog]], [[2x2r]], [[2xae]], [[4bbg]] – hKIFL 11 +S-trityl-L-cysteine derivative + ADP + Mg<br /> |
| - | **[[3wpn]] | + | **[[3wpn]] – hKIFL 11 +inhibitor <br /> |
| - | **[[2uyi]], [[2uym]], [[2gm1]], [[2pg2]], [[2fme]], [[2x7d]], [[2x7c]], [[2ieh]], [[3cjo]], [[2g1q]], [[2fl2]], [[2fl6]], [[1yrs]], [[2q2y]], [[2fky]], [[2q2z]], [[3k3b]], [[2x7e]], [[4a50]], [[4a51]], [[3zcw]], [[6g6y]], [[6g6z]], [[6hkx]], [[6hky]] - hKIF11+inhibitor +ADP + Mg<br /> | + | **[[2uyi]], [[2uym]], [[2gm1]], [[2pg2]], [[2fme]], [[2x7d]], [[2x7c]], [[2ieh]], [[3cjo]], [[2g1q]], [[2fl2]], [[2fl6]], [[1yrs]], [[2q2y]], [[2fky]], [[2q2z]], [[3k3b]], [[2x7e]], [[4a50]], [[4a51]], [[3zcw]], [[6g6y]], **[[6g6z]], [[6hkx]], [[6hky]] - hKIF11+inhibitor +ADP + Mg<br /> |
| - | **[[4bxn]], [[4as7]] | + | **[[4bxn]], [[4as7]] – hKIFL 11+inhibitor +ADP + Cd<br /> |
| - | **[[3l9h]] | + | **[[3l9h]] – hKIFL 11+inhibitor +ADP <br /> |
| - | **[[4zhi]] – | + | **[[4zhi]] – hKIFL 11 MD +ADP<br /> |
| - | **[[1x88]], [[1q0b]] | + | **[[1x88]], [[1q0b]] – hKIFL 11 +Mg + ADP+monastrol <br /> |
| - | **[[4ap0]], [[4a5y]] | + | **[[4ap0]], [[4a5y]] – hKIFL 11 +MgADP + ispinesib + Mg<br /> |
| - | **[[3hqd]] | + | **[[3hqd]] – hKIFL 11 +AMPPNP+Mg<br /> |
| - | **[[1ii6]], [[4a1z]], [[4a28]] | + | **[[1ii6]], [[4a1z]], [[4a28]] – hKIFL11 +ADP+Mg<br /> |
| - | **[[4zca]], [[6tle]], [[6trl]], [[6y1i]] | + | **[[4zca]], [[6tle]], [[6trl]], [[6y1i]] – hKIFL 11 (mutant) +ADP+Mg<br /> |
| - | **[[3k5e]] | + | **[[3k5e]] – hKIFL 11 +ADP+enastrol + Mg<br /> |
| - | + | **[[4aqv]], [[4aqw]] – hKIFL 11 (mutant) + tubulin + GDP + GTP + Mg – Cryo EM<br /> | |
| - | **[[4aqv]], [[4aqw]] – | + | **[[4ck5]], [[4ck6]], [[4ck7]] – hKIFL 11 (mutant) + tubulin + ADP + GDP + GTP + Mg – Cryo EM<br /> |
| - | **[[4ck5]], [[4ck6]], [[4ck7]] – | + | **[[6ta3]], [[6tiw]] – hKIFL 11 MD (mutant) + tubulin + G2P + quinolin derivative + Mg – Cryo EM<br /> |
| - | **[[6ta3]], [[6tiw]] – | + | **[[6ta4]] – hKIFL 11 MD + tubulin + G2P + ANP + Mg – Cryo EM<br /> |
| - | **[[6ta4]] – | + | **[[5m5i]], [[5m5l]], [[5m5m]], [[5m5n]], [[5m5o]] – fyKIFL Cut7 MD + tubulin + GDP + GTP + ANP + taxol – fission yeast – Cryo EM<br /> |
| - | **[[5m5i]], [[5m5l]], [[5m5m]], [[5m5n]], [[5m5o]] – | + | **[[6s8m]] – fyKIFL Cut7 MD + tubulin + GDP + GTP + ANP – Cryo EM<br /> |
| - | **[[6s8m]] – | + | |
| - | **[[5mm4]], [[5mm7]] – UmKIF + tubulin + GDP + GTP + ANP + taxol – | + | *KIF11 |
| + | |||
| + | **[[5mm4]], [[5mm7]] – UmKIF + tubulin + GDP + GTP + ANP + taxol – Ustilago maydis – Cryo EM<br /> | ||
**[[7nb8]] – PfKIF MD + tubulin + GTP + G2P – ''Plasmodium falciparum'' – Cryo EM<br /> | **[[7nb8]] – PfKIF MD + tubulin + GTP + G2P – ''Plasmodium falciparum'' – Cryo EM<br /> | ||
**[[7nba]] – PfKIF MD + tubulin + GTP + G2P + ANP – Cryo EM<br /> | **[[7nba]] – PfKIF MD + tubulin + GTP + G2P + ANP – Cryo EM<br /> | ||
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*KIF13A, KIF13B or kinesin-3 | *KIF13A, KIF13B or kinesin-3 | ||
| - | **[[2cow]] – hKIF13B CAP-gly domain – NMR<br /> | ||
**[[3gbj]] – hKIF13B MD+ADP <br /> | **[[3gbj]] – hKIF13B MD+ADP <br /> | ||
| - | + | **[[5b64]] – mKIF13B MBS domain + MAGUK<br /> | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | **[[5b64]] – mKIF13B + MAGUK<br /> | + | |
**[[3kin]], [[2kin]] – rKIF MD <br /> | **[[3kin]], [[2kin]] – rKIF MD <br /> | ||
**[[6a1z]] – rKIF13B<br /> | **[[6a1z]] – rKIF13B<br /> | ||
**[[5zbs]], [[6a20]], [[7d8v]] – rKIF13B (mutant)<br /> | **[[5zbs]], [[6a20]], [[7d8v]] – rKIF13B (mutant)<br /> | ||
**[[7d8v]] – rKIF13B (mutant) + ADP<br /> | **[[7d8v]] – rKIF13B (mutant) + ADP<br /> | ||
| - | **[[5zbr]] – rKIF13B + AMPPNP<br /> | + | **[[5zbr]] – rKIF13B MD + AMPPNP<br /> |
| - | * | + | * KIF-like 13B |
| - | **[[ | + | **[[2cow]] – hKIFL 13B CAP-gly domain – NMR<br /> |
| - | **[[ | + | **[[3fm8]] – hKIFL 13B FHA domain + centaurin-alpha-1<br /> |
| - | **[[ | + | **[[5djo]] – mKIFL 13A CC1-FHA domain <br /> |
| - | **[[ | + | **[[5djn]] – mKIFL 13A coiled-coil domain (mutant)<br /> |
| - | * | + | *KIF-like 14 or kinesin-3 |
| - | **[[ | + | **[[6wwe]], [[6wwi]], [[6wwt]] – hKIF14L MD + Tubulin + GTP + GDP – Cryo EM<br /> |
| - | **[[ | + | **[[6wwf]], [[6wwh]], [[6wwg]], [[6wwj]], [[6wwk]], [[6wwl]], [[6wwm]], [[6wwn]], [[6wwo]], [[6wwp]], [[6wwq]], [[6wwr]], [[6wws]], [[6wwu]], [[6wwv]], [[7lvq]], [[7lvr]] – mKIF14L MD + Tubulin + nucleotides – Cryo EM<br /> |
| - | * | + | *KIF-like Kar3 |
| - | **[[ | + | **[[1f9t]], [[1f9u]], [[1f9v]], [[1f9w]], [[3kar]] – yKIFL Kar3 MD (mutant) – yeast<br /> |
| - | **[[ | + | **[[4etp]] – yKIFL Kar3 MD (mutant) + VIK1<br /> |
| - | * | + | *KIF-like 15 or kinesin-12 |
| - | **[[ | + | **[[4bn2]] – hKIFL 15 MD<br /> |
| - | **[[ | + | **[[7ryp]] – hKIFL 15 MD + KIF-binding protein – Cryo EM<br /> |
| - | **[[ | + | **[[6zpi]] – hKIFL 15 MD + tubulin + GDP + GTP + Mg – Cryo EM<br /> |
| - | + | ||
| - | + | ||
| - | * | + | *KIF-like 16B or kinesin-3 |
| - | **[[ | + | **[[2v14]], [[6ee0]] – hKIFL 16B PX homology domain 1179-1312<br /> |
| - | + | ||
| - | * | + | *KIF-like 18A or kinesin-8 |
| - | **[[ | + | **[[3lre]] – hKIFL 18A MD <br /> |
| - | **[[ | + | **[[5oam]] – hKIFL 18A MD + tubulin + GTP<br /> |
| - | **[[ | + | **[[5ocu]] – hKIFL 18A MD + tubulin + GTP + GDP + ANP<br /> |
| - | **[[ | + | **[[5ogc]] – hKIFL 18A MD + tubulin + GTP + GDP + taxol<br /> |
| - | **[[ | + | **[[7rsi]] – hKIFL 18A MD + KIF-binding protein + ADP – Cryo EM<br /> |
| - | + | ||
| - | * | + | *KIF-like 19A or kinesin-8 |
| - | **[[ | + | **[[5gsy]] – mKIFL 19A MD + GDP<br /> |
| - | **[[ | + | **[[5gsz]] – mKIFL 19A MD + ADP<br /> |
| - | * | + | *KIF-like 20A or kinesin-6 |
| - | **[[2edu]] – | + | **[[6yip]] – hKIFL 20A coiled coil domain 596-668 <br /> |
| - | **[[6nje]] – | + | **[[5nd3]] – mKIFL 20A MD + tubulin <br /> |
| + | **[[5nd2]], [[5nd4]] – mKIFL 20A MD + tubulin + ADP <br /> | ||
| + | **[[5nd7]] – mKIFL 20A MD + tubulin + AMPPNP <br /> | ||
| + | **[[5lef]] – mKIFL 20A residues 603-665 + RAB-6 <br /> | ||
| + | **[[5x3e]] - KIFL MD - Caenorhabditis elegans<br /> | ||
| + | |||
| + | *KIF-like 21A or kinesin-4 | ||
| + | |||
| + | **[[5d3a]] – hKIFL 21A coiled coil domain 938-1017 <br /> | ||
| + | **[[7klj]] – hKIFL 21A WD-repeat domain 1324-1640 <br /> | ||
| + | |||
| + | *KIF-like 22 or kinesin-10 | ||
| + | |||
| + | **[[2edu]] – hKIFL 22 C-terminal – NMR<br /> | ||
| + | **[[6nje]] – hKIFL 22 MD +ADP<br /> | ||
*KIF23 or kinesin-6 | *KIF23 or kinesin-6 | ||
| - | **[[3vhx]] – | + | **[[3vhx]] – hKIFL 23 794-911 + ADP-ribosylation factor 6 <br /> |
| - | **[[2ncd]], [[1cz7]] – DmKIF MD non-claret disjuctional (NCD) dimer | + | **[[2ncd]], [[1cz7]] – DmKIF MD non-claret disjuctional (NCD) dimer <br /> |
| - | + | ||
| - | + | ||
| - | + | ||
**[[3l1c]] – DmNCD (mutant)<br /> | **[[3l1c]] – DmNCD (mutant)<br /> | ||
| + | |||
**[[1ry6]] – PfKIF MD <br /> | **[[1ry6]] – PfKIF MD <br /> | ||
**[[7nba]] – PfKlF + tubulin + GTP + G2P + ANP + Mg – Cryo EM<br /> | **[[7nba]] – PfKlF + tubulin + GTP + G2P + ANP + Mg – Cryo EM<br /> | ||
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**[[6fv0]] – mKLC1 TPR domain + nanobody<br /> | **[[6fv0]] – mKLC1 TPR domain + nanobody<br /> | ||
**[[5ojf]] – mKLC2 TPR domain <br /> | **[[5ojf]] – mKLC2 TPR domain <br /> | ||
| - | **[[3zfw]], [[5fjy]], [[6ejn]], [[6swu]] - mKLC2 TPR domain + peptide<br /> | + | **[[3zfw]], [[5fjy]], [[6ejn]], [[6swu]] - mKLC2 TPR domain + peptide<br /> |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
*NOD | *NOD | ||
| Line 207: | Line 214: | ||
**[[3dcb]] - DmNOD catalytic core domain+AMPPNP + Mg<br /> | **[[3dcb]] - DmNOD catalytic core domain+AMPPNP + Mg<br /> | ||
**[[3dco]] - DmNOD catalytic core domain+ cTubulin + ADP + GDP + GTP + Mg<br /> | **[[3dco]] - DmNOD catalytic core domain+ cTubulin + ADP + GDP + GTP + Mg<br /> | ||
| + | **[[3pxn]] - DmNOD catalytic core domain+ADP + Mn<br /> | ||
}} | }} | ||
| - | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
3D Structures of Kinesin
Updated on 10-May-2024
