8j4i

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:16, 5 June 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8j4i is ON HOLD until 2025-04-20
+
==Unveiling the Role of Human Prohibitin 2 as a Mitochondrial Calcium Channel in Parkinson's Disease==
-
 
+
<StructureSection load='8j4i' size='340' side='right'caption='[[8j4i]]' scene=''>
-
Authors: Li, Y.Y., Fang, Y., Gao, Y.X., Ding, W., Yang, J., Liu, Y., Shen, B., Wang, J.F., Zhou, S.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8j4i]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J4I FirstGlance]. <br>
-
Description: Human Prohibitin 2 is a Mitochondrial Ca2+-Selective Channel
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j4i OCA], [https://pdbe.org/8j4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j4i RCSB], [https://www.ebi.ac.uk/pdbsum/8j4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j4i ProSAT]</span></td></tr>
-
[[Category: Fang, Y]]
+
</table>
-
[[Category: Yang, J]]
+
== Function ==
-
[[Category: Zhou, S]]
+
[https://www.uniprot.org/uniprot/PHB2_HUMAN PHB2_HUMAN] Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus.<ref>PMID:10359819</ref> <ref>PMID:11302691</ref> <ref>PMID:20959514</ref> <ref>PMID:24003225</ref> <ref>PMID:28017329</ref> <ref>PMID:31522117</ref> In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration (PubMed:11302691, PubMed:20959514). Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:11302691, PubMed:20959514). Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117).[UniProtKB:O35129]<ref>PMID:11302691</ref> <ref>PMID:20959514</ref> <ref>PMID:28017329</ref> <ref>PMID:31522117</ref> <ref>PMID:25904163</ref> In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity (By similarity).[UniProtKB:O35129]<ref>PMID:25904163</ref> In the plasma membrane, is involved in IGFBP6-induced cell migration (PubMed:24003225). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).[UniProtKB:O35129]<ref>PMID:24003225</ref> (Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection.<ref>PMID:32276428</ref>
-
[[Category: Shen, B]]
+
== References ==
-
[[Category: Wang, J.F]]
+
<references/>
-
[[Category: Liu, Y]]
+
__TOC__
-
[[Category: Ding, W]]
+
</StructureSection>
-
[[Category: Li, Y.Y]]
+
[[Category: Homo sapiens]]
-
[[Category: Gao, Y.X]]
+
[[Category: Large Structures]]
 +
[[Category: Ding W]]
 +
[[Category: Fang Y]]
 +
[[Category: Gao YX]]
 +
[[Category: Li YY]]
 +
[[Category: Liu Y]]
 +
[[Category: Shen B]]
 +
[[Category: Wang JF]]
 +
[[Category: Yang J]]
 +
[[Category: Zhou S]]

Current revision

Unveiling the Role of Human Prohibitin 2 as a Mitochondrial Calcium Channel in Parkinson's Disease

PDB ID 8j4i

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8j4i"
Personal tools