1l1w

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[[Image:1l1w.gif|left|200px]]
 
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==NMR structure of a SRP19 binding domain in human SRP RNA==
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The line below this paragraph, containing "STRUCTURE_1l1w", creates the "Structure Box" on the page.
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<StructureSection load='1l1w' size='340' side='right'caption='[[1l1w]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1l1w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L1W FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1w OCA], [https://pdbe.org/1l1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l1w RCSB], [https://www.ebi.ac.uk/pdbsum/1l1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1w ProSAT]</span></td></tr>
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{{STRUCTURE_1l1w| PDB=1l1w | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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'''NMR structure of a SRP19 binding domain in human SRP RNA'''
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== Publication Abstract from PubMed ==
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==Overview==
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Assembly of the human signal recognition particle (SRP) requires SRP19 protein to bind to helices 6 and 8 of SRP RNA. In the present study, structure of a 29-mer RNA composing the SRP19 binding site in helix 6 was determined by NMR spectroscopy. The two A:C mismatches were continuously stacked to each other and formed wobble type A:C base pairs. The GGAG tetraloop in helix 6 was found to adopt a similar conformation to that of GNRA tetraloop, suggesting that these tetraloops are included in an extensive new motif GNRR. Compared with the crystal structure of helix 6 in complex with SRP19 determined previously, the GGAG tetraloop in the complex was found to adopt a similar conformation to the free form, although the loop structure becomes more open upon SRP19 binding. Thus, SRP19 is thought to recognize the overall fold of the GGAG loop.
Assembly of the human signal recognition particle (SRP) requires SRP19 protein to bind to helices 6 and 8 of SRP RNA. In the present study, structure of a 29-mer RNA composing the SRP19 binding site in helix 6 was determined by NMR spectroscopy. The two A:C mismatches were continuously stacked to each other and formed wobble type A:C base pairs. The GGAG tetraloop in helix 6 was found to adopt a similar conformation to that of GNRA tetraloop, suggesting that these tetraloops are included in an extensive new motif GNRR. Compared with the crystal structure of helix 6 in complex with SRP19 determined previously, the GGAG tetraloop in the complex was found to adopt a similar conformation to the free form, although the loop structure becomes more open upon SRP19 binding. Thus, SRP19 is thought to recognize the overall fold of the GGAG loop.
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==About this Structure==
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Solution structure of a SRP19 binding domain in human SRP RNA.,Sakamoto T, Morita S, Tabata K, Nakamura K, Kawai G J Biochem. 2002 Aug;132(2):177-82. PMID:12153712<ref>PMID:12153712</ref>
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1W OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Solution structure of a SRP19 binding domain in human SRP RNA., Sakamoto T, Morita S, Tabata K, Nakamura K, Kawai G, J Biochem. 2002 Aug;132(2):177-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12153712 12153712]
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</div>
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[[Category: Kawai, G.]]
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<div class="pdbe-citations 1l1w" style="background-color:#fffaf0;"></div>
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[[Category: Morita, S.]]
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== References ==
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[[Category: Nakamura, K.]]
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<references/>
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[[Category: Sakamoto, T.]]
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__TOC__
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[[Category: Tabata, K.]]
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</StructureSection>
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[[Category: Gnrr]]
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[[Category: Homo sapiens]]
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[[Category: Mismatch]]
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[[Category: Large Structures]]
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[[Category: Rna hairpin]]
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[[Category: Kawai G]]
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[[Category: Tetraloop]]
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[[Category: Morita S]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:26:58 2008''
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[[Category: Nakamura K]]
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[[Category: Sakamoto T]]
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[[Category: Tabata K]]

Current revision

NMR structure of a SRP19 binding domain in human SRP RNA

PDB ID 1l1w

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