8p7q
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The entry 8p7q is | + | ==The impact of molecular variants, crystallization conditions and space group on structure-ligand complexes: A case study on Bacterial Phosphotriesterase Variants and complexes== |
| + | <StructureSection load='8p7q' size='340' side='right'caption='[[8p7q]], [[Resolution|resolution]] 1.77Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8p7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevundimonas_diminuta Brevundimonas diminuta]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6fvk 6fvk]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P7Q FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E8N:1-ethyl-1-methyl-cyclohexane'>E8N</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UCJ:propan-2-yl+hydrogen+(S)-methylphosphonate'>UCJ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p7q OCA], [https://pdbe.org/8p7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p7q RCSB], [https://www.ebi.ac.uk/pdbsum/8p7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p7q ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/OPD_BREDI OPD_BREDI] Has an unusual substrate specificity for synthetic organophosphate triesters and phosphorofluoridates. All of the phosphate triesters found to be substrates are synthetic compounds. The identity of any naturally occurring substrate for the enzyme is unknown. Has no detectable activity with phosphate monoesters or diesters and no activity as an esterase or protease. It catalyzes the hydrolysis of the insecticide paraoxon at a rate approaching the diffusion limit and thus appears to be optimally evolved for utilizing this synthetic substrate. | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphotriesterase 3D structures|Phosphotriesterase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Brevundimonas diminuta]] |
| - | [[Category: Albeck | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Aggarwal N]] |
| - | [[Category: | + | [[Category: Albeck S]] |
| - | [[Category: | + | [[Category: Ashani Y]] |
| - | [[Category: | + | [[Category: Dym O]] |
| - | [[Category: | + | [[Category: Hamer Rogotner S]] |
| - | [[Category: | + | [[Category: Silman I]] |
| + | [[Category: Sussman JL]] | ||
| + | [[Category: Unger T]] | ||
Current revision
The impact of molecular variants, crystallization conditions and space group on structure-ligand complexes: A case study on Bacterial Phosphotriesterase Variants and complexes
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