8pae
From Proteopedia
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(New page: '''Unreleased structure''' The entry 8pae is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the ectodomain of Atypical Porcine Pestivirus E2 at 1.2A resolution== | |
| + | <StructureSection load='8pae' size='340' side='right'caption='[[8pae]], [[Resolution|resolution]] 1.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8pae]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atypical_porcine_pestivirus Atypical porcine pestivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PAE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PAE FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pae OCA], [https://pdbe.org/8pae PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pae RCSB], [https://www.ebi.ac.uk/pdbsum/8pae PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pae ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A1B1M0D5_9FLAV A0A1B1M0D5_9FLAV] Acts as a cofactor for the NS3 protease activity.[ARBA:ARBA00023576] Packages viral RNA to form a viral nucleocapsid and thereby protects viral RNA. Also plays a role in transcription regulation. Protects the incoming virus against IFN-induced effectors.[ARBA:ARBA00034097] Plays a role in the regulation of viral RNA replication.[ARBA:ARBA00023574] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Pestiviruses, within the family Flaviviridae, are economically important viruses of livestock. In recent years, new pestiviruses have been reported in domestic animals and non-cloven-hoofed animals. Among them, atypical porcine pestivirus (APPV) and Norway rat pestivirus (NRPV) have relatively little sequence conservation in their surface glycoprotein E2. Despite E2 being the main target for neutralizing antibodies and necessary for cell attachment and viral fusion, the mechanism of viral entry remains elusive. To gain further insights into the pestivirus E2 mechanism of action and to assess its diversity within the genus, we report X-ray structures of the pestivirus E2 proteins from APPV and NRPV. Despite the highly divergent structures, both are able to dimerize through their C-terminal domain and contain a solvent-exposed beta-hairpin reported to be involved in host receptor binding. Functional analysis of this beta-hairpin in the context of BVDV revealed its ability to rescue viral infectivity. | ||
| - | + | Structural comparison of typical and atypical E2 pestivirus glycoproteins.,Aitkenhead H, Riedel C, Cowieson N, Rumenapf HT, Stuart DI, El Omari K Structure. 2024 Mar 7;32(3):273-281.e4. doi: 10.1016/j.str.2023.12.003. Epub 2024 , Jan 3. PMID:38176409<ref>PMID:38176409</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 8pae" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Atypical porcine pestivirus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Aitkenhead H]] | ||
| + | [[Category: EL Omari K]] | ||
| + | [[Category: Stuart DI]] | ||
Current revision
Structure of the ectodomain of Atypical Porcine Pestivirus E2 at 1.2A resolution
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