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8syo

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Current revision (13:15, 1 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8syo is ON HOLD until Paper Publication
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==Human Retriever VPS35L/VPS29/VPS26C Complex (Composite Map)==
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<StructureSection load='8syo' size='340' side='right'caption='[[8syo]], [[Resolution|resolution]] 2.94&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8syo]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SYO FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.94&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8syo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8syo OCA], [https://pdbe.org/8syo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8syo RCSB], [https://www.ebi.ac.uk/pdbsum/8syo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8syo ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/VP35L_HUMAN VP35L_HUMAN] The disease may be caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/VP35L_HUMAN VP35L_HUMAN] Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (PubMed:28892079). In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (PubMed:28892079). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association with the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability (PubMed:25355947).<ref>PMID:25355947</ref> <ref>PMID:28892079</ref> (Microbial infection) The heterotrimeric retriever complex, in collaboration with the CCC complex, mediates the exit of human papillomavirus to the cell surface.<ref>PMID:28892079</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Burstein E]]
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[[Category: Chen B]]
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[[Category: Chen Z]]
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[[Category: Han Y]]

Current revision

Human Retriever VPS35L/VPS29/VPS26C Complex (Composite Map)

PDB ID 8syo

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