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1l2y

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[[Image:1l2y.gif|left|200px]]
 
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==NMR Structure of Trp-Cage Miniprotein Construct TC5b==
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The line below this paragraph, containing "STRUCTURE_1l2y", creates the "Structure Box" on the page.
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<StructureSection load='1l2y' size='340' side='right'caption='[[1l2y]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1l2y]] is a 1 chain structure. The October 2005 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Designer Proteins'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2005_10 10.2210/rcsb_pdb/mom_2005_10]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L2Y FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2y OCA], [https://pdbe.org/1l2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l2y RCSB], [https://www.ebi.ac.uk/pdbsum/1l2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2y ProSAT]</span></td></tr>
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{{STRUCTURE_1l2y| PDB=1l2y | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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'''NMR Structure of Trp-Cage Miniprotein Construct TC5b'''
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== Publication Abstract from PubMed ==
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==Overview==
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Truncation and mutation of a poorly folded 39-residue peptide has produced 20-residue constructs that are &gt;95% folded in water at physiological pH. These constructs optimize a novel fold, designated as the 'Trp-cage' motif, and are significantly more stable than any other miniprotein reported to date. Folding is cooperative and hydrophobically driven by the encapsulation of a Trp side chain in a sheath of Pro rings. As the smallest protein-like construct, Trp-cage miniproteins should provide a testing ground for both experimental studies and computational simulations of protein folding and unfolding pathways. Pro Trp interactions may be a particularly effective strategy for the a priori design of self-folding peptides.
Truncation and mutation of a poorly folded 39-residue peptide has produced 20-residue constructs that are &gt;95% folded in water at physiological pH. These constructs optimize a novel fold, designated as the 'Trp-cage' motif, and are significantly more stable than any other miniprotein reported to date. Folding is cooperative and hydrophobically driven by the encapsulation of a Trp side chain in a sheath of Pro rings. As the smallest protein-like construct, Trp-cage miniproteins should provide a testing ground for both experimental studies and computational simulations of protein folding and unfolding pathways. Pro Trp interactions may be a particularly effective strategy for the a priori design of self-folding peptides.
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==About this Structure==
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Designing a 20-residue protein.,Neidigh JW, Fesinmeyer RM, Andersen NH Nat Struct Biol. 2002 Jun;9(6):425-30. PMID:11979279<ref>PMID:11979279</ref>
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The following page contains interesting information on the relation of 1L2Y with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2Y OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Designing a 20-residue protein., Neidigh JW, Fesinmeyer RM, Andersen NH, Nat Struct Biol. 2002 Jun;9(6):425-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11979279 11979279]
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</div>
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<div class="pdbe-citations 1l2y" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Designer Proteins]]
[[Category: Designer Proteins]]
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[[Category: Andersen, N H.]]
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[[Category: Large Structures]]
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[[Category: Fesinmeyer, R M.]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Neidigh, J W.]]
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[[Category: Andersen NH]]
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[[Category: Miniprotein]]
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[[Category: Fesinmeyer RM]]
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[[Category: Trp-cage]]
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[[Category: Neidigh JW]]
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[[Category: Two-state folding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:28:53 2008''
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Current revision

NMR Structure of Trp-Cage Miniprotein Construct TC5b

PDB ID 1l2y

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