| Structural highlights
Function
DEFLU_LUCSE Shows strong antibacterial activity against numerous Gram-positive bacteria. It selectively inhibits peptidoglycan biosynthesis through complex formation with the cell wall precursor lipid II (1:1 molar ratio) thus inhibiting cell wall synthesis (PubMed:20508130). Shows antibacterial activity against the Gram-positive bacteria M.luteus, E.fecalis (MIC=32 mg/L), S.aureus (MIC=16 mg/L), S.carnosus (MIC=2 mg/L), S.pneumoniae (MIC=2 mg/L) and S.pyogenes (MIC=2 mg/L) and against a number of methicillin-resistant S.aureus and glycopeptide-intermediate S.aureus isolates (PubMed:20542901, PubMed:19921400, PubMed:21560219). Does not show antibacterial activity against Gram-negative bacteria or antifungal activity against C.utilis (PubMed:20542901). Shows slight antifungal activity against C.albicans (PubMed:21560219).[1] [2] [3] [4]
References
- ↑ Cerovský V, Zdárek J, Fucík V, Monincová L, Voburka Z, Bém R. Lucifensin, the long-sought antimicrobial factor of medicinal maggots of the blowfly Lucilia sericata. Cell Mol Life Sci. 2010 Feb;67(3):455-66. PMID:19921400 doi:10.1007/s00018-009-0194-0
- ↑ Andersen AS, Sandvang D, Schnorr KM, Kruse T, Neve S, Joergensen B, Karlsmark T, Krogfelt KA. A novel approach to the antimicrobial activity of maggot debridement therapy. J Antimicrob Chemother. 2010 Aug;65(8):1646-54. PMID:20542901 doi:10.1093/jac/dkq165
- ↑ Ceřovský V, Slaninová J, Fučík V, Monincová L, Bednárová L, Maloň P, Stokrová J. Lucifensin, a novel insect defensin of medicinal maggots: synthesis and structural study. Chembiochem. 2011 Jun 14;12(9):1352-61. PMID:21560219 doi:10.1002/cbic.201100066
- ↑ Schneider T, Kruse T, Wimmer R, Wiedemann I, Sass V, Pag U, Jansen A, Nielsen AK, Mygind PH, Raventós DS, Neve S, Ravn B, Bonvin AM, De Maria L, Andersen AS, Gammelgaard LK, Sahl HG, Kristensen HH. Plectasin, a fungal defensin, targets the bacterial cell wall precursor Lipid II. Science. 2010 May 28;328(5982):1168-72. PMID:20508130 doi:10.1126/science.1185723
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