8p0g
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Thogoto virus polymerase in Mode A conformation and bound to 35-mer loop promoter RNA== | |
| - | + | <StructureSection load='8p0g' size='340' side='right'caption='[[8p0g]], [[Resolution|resolution]] 3.17Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8p0g]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Thogoto_thogotovirus Thogoto thogotovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P0G FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.17Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p0g OCA], [https://pdbe.org/8p0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p0g RCSB], [https://www.ebi.ac.uk/pdbsum/8p0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p0g ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RDRP_THOGV RDRP_THOGV] RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA. In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.[UniProtKB:P03431] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Thogoto thogotovirus]] | ||
| + | [[Category: Cusack S]] | ||
| + | [[Category: Kouba T]] | ||
Current revision
Thogoto virus polymerase in Mode A conformation and bound to 35-mer loop promoter RNA
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