8pf4
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8pf4 is ON HOLD Authors: Exertier, C., Ilari, A., Fiorillo, A., Antonelli, L. Description: Crystal structure of Trypanosoma brucei trypanothione re...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Trypanosoma brucei trypanothione reductase in complex with 4-(((5-((4-fluorophenethyl)carbamoyl)furan-2-yl)methyl)(4-fluorophenyl)carbamoyl)-1-methyl-1-(3-phenylpropyl)piperazin-1-ium== | |
| - | + | <StructureSection load='8pf4' size='340' side='right'caption='[[8pf4]], [[Resolution|resolution]] 1.84Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8pf4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PF4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=YIA:~{N}-(4-fluorophenyl)-~{N}-[[5-[2-(4-fluorophenyl)ethylcarbamoyl]furan-2-yl]methyl]-4-methyl-4-(3-phenylpropyl)-1,4$l^{4}-diazinane-1-carboxamide'>YIA</scene></td></tr> |
| - | [[Category: Antonelli | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pf4 OCA], [https://pdbe.org/8pf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pf4 RCSB], [https://www.ebi.ac.uk/pdbsum/8pf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pf4 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Fiorillo | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/A0A3L6KZJ1_9TRYP A0A3L6KZJ1_9TRYP] Trypanothione is the parasite analog of glutathione; this enzyme is the equivalent of glutathione reductase.[ARBA:ARBA00003667] |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Trypanosoma brucei]] | ||
| + | [[Category: Antonelli L]] | ||
| + | [[Category: Exertier C]] | ||
| + | [[Category: Fiorillo A]] | ||
| + | [[Category: Ilari A]] | ||
Current revision
Crystal structure of Trypanosoma brucei trypanothione reductase in complex with 4-(((5-((4-fluorophenethyl)carbamoyl)furan-2-yl)methyl)(4-fluorophenyl)carbamoyl)-1-methyl-1-(3-phenylpropyl)piperazin-1-ium
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