1lb6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:31, 14 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1lb6.gif|left|200px]]
 
-
<!--
+
==TRAF6-CD40 Complex==
-
The line below this paragraph, containing "STRUCTURE_1lb6", creates the "Structure Box" on the page.
+
<StructureSection load='1lb6' size='340' side='right'caption='[[1lb6]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1lb6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LB6 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lb6 OCA], [https://pdbe.org/1lb6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lb6 RCSB], [https://www.ebi.ac.uk/pdbsum/1lb6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lb6 ProSAT]</span></td></tr>
-
{{STRUCTURE_1lb6| PDB=1lb6 | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TRAF6_HUMAN TRAF6_HUMAN] E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.<ref>PMID:8837778</ref> <ref>PMID:11057907</ref> <ref>PMID:16378096</ref> <ref>PMID:17135271</ref> <ref>PMID:18093978</ref> <ref>PMID:18758450</ref> <ref>PMID:19675569</ref> <ref>PMID:19713527</ref> <ref>PMID:12140561</ref> <ref>PMID:19465916</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lb/1lb6_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lb6 ConSurf].
 +
<div style="clear:both"></div>
-
'''TRAF6-CD40 Complex'''
+
==See Also==
-
 
+
*[[TNF receptor-associated factor 3D structures|TNF receptor-associated factor 3D structures]]
-
 
+
== References ==
-
==Overview==
+
<references/>
-
Tumour-necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is the only TRAF family member that participates in signal transduction of both the TNF receptor (TNFR) superfamily and the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily; it is important for adaptive immunity, innate immunity and bone homeostasis. Here we report crystal structures of TRAF6, alone and in complex with TRAF6-binding peptides from CD40 and TRANCE-R (also known as RANK), members of the TNFR superfamily, to gain insight into the mechanism by which TRAF6 mediates several signalling cascades. A 40 degrees difference in the directions of the bound peptides in TRAF6 and TRAF2 shows that there are marked structural differences between receptor recognition by TRAF6 and other TRAFs. The structural determinant of the petide TRAF6 interaction reveals a Pro-X-Glu-X-X-(aromatic/acidic residue) TRAF6-binding motif, which is present not only in CD40 and TRANCE-R but also in the three IRAK adapter kinases for IL-1R/TLR signalling. Cell-permeable peptides with the TRAF6-binding motif inhibit TRAF6 signalling, which indicates their potential as therapeutic modulators. Our studies identify a universal mechanism by which TRAF6 regulates several signalling cascades in adaptive immunity, innate immunity and bone homeostasis.
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
1LB6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB6 OCA].
+
-
 
+
-
==Reference==
+
-
Distinct molecular mechanism for initiating TRAF6 signalling., Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, Segal D, Dzivenu OK, Vologodskaia M, Yim M, Du K, Singh S, Pike JW, Darnay BG, Choi Y, Wu H, Nature. 2002 Jul 25;418(6896):443-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12140561 12140561]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Protein complex]]
+
[[Category: Large Structures]]
-
[[Category: Arron, J R.]]
+
[[Category: Arron JR]]
-
[[Category: Choi, Y.]]
+
[[Category: Choi Y]]
-
[[Category: Cirilli, M.]]
+
[[Category: Cirilli M]]
-
[[Category: Darnay, B G.]]
+
[[Category: Darnay BG]]
-
[[Category: Du, K.]]
+
[[Category: Du K]]
-
[[Category: Dzivenu, O.]]
+
[[Category: Dzivenu O]]
-
[[Category: Kobayashi, T.]]
+
[[Category: Kobayashi T]]
-
[[Category: Lamothe, B.]]
+
[[Category: Lamothe B]]
-
[[Category: Pike, J W.]]
+
[[Category: Pike JW]]
-
[[Category: Segal, D.]]
+
[[Category: Segal D]]
-
[[Category: Shevde, N K.]]
+
[[Category: Shevde NK]]
-
[[Category: Singh, S.]]
+
[[Category: Singh S]]
-
[[Category: Vologodskaia, M.]]
+
[[Category: Vologodskaia M]]
-
[[Category: Wu, H.]]
+
[[Category: Wu H]]
-
[[Category: Ye, H.]]
+
[[Category: Ye H]]
-
[[Category: Yim, M.]]
+
[[Category: Yim M]]
-
[[Category: Traf6-cd40 complex]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:44:43 2008''
+

Current revision

TRAF6-CD40 Complex

PDB ID 1lb6

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1lb6"
Personal tools