8p5p
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of TECPR1 N-terminal DysF domain== | |
| - | + | <StructureSection load='8p5p' size='340' side='right'caption='[[8p5p]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8p5p]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P5P FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p5p OCA], [https://pdbe.org/8p5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p5p RCSB], [https://www.ebi.ac.uk/pdbsum/8p5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p5p ProSAT]</span></td></tr> |
| - | [[Category: Elliott | + | </table> |
| - | [[Category: | + | == Function == |
| + | [https://www.uniprot.org/uniprot/TCPR1_HUMAN TCPR1_HUMAN] Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.<ref>PMID:21575909</ref> <ref>PMID:22342342</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Boyle KB]] | ||
| + | [[Category: Elliott PR]] | ||
| + | [[Category: Randow F]] | ||
Current revision
Structure of TECPR1 N-terminal DysF domain
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