8pj3

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(New page: '''Unreleased structure''' The entry 8pj3 is ON HOLD Authors: Description: Category: Unreleased Structures)
Current revision (08:16, 14 August 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8pj3 is ON HOLD
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==Structure of human 48S translation initiation complex upon transfer of initiator tRNA to eIF5B (48S-3)==
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<StructureSection load='8pj3' size='340' side='right'caption='[[8pj3]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8pj3]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PJ3 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pj3 OCA], [https://pdbe.org/8pj3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pj3 RCSB], [https://www.ebi.ac.uk/pdbsum/8pj3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pj3 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/RS19_HUMAN RS19_HUMAN] Blackfan-Diamond disease. Diamond-Blackfan anemia 1 (DBA1) [MIM:[https://omim.org/entry/105650 105650]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of developing leukemia. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:17517689</ref> <ref>PMID:12586610</ref> <ref>PMID:9988267</ref> <ref>PMID:10590074</ref> <ref>PMID:11112378</ref> <ref>PMID:12750732</ref> <ref>PMID:15384984</ref> [REFERENCE:18]
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== Function ==
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[https://www.uniprot.org/uniprot/RS19_HUMAN RS19_HUMAN] Required for pre-rRNA processing and maturation of 40S ribosomal subunits.<ref>PMID:16990592</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Fischer N]]
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[[Category: Liedtke D]]
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[[Category: Peng BZ]]
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[[Category: Petrychenko V]]
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[[Category: Rodnina MV]]
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[[Category: Yi S-H]]

Current revision

Structure of human 48S translation initiation complex upon transfer of initiator tRNA to eIF5B (48S-3)

PDB ID 8pj3

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