Microtubule-associated serine/threonine kinase
From Proteopedia
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'''Microtubule_associated serine/threonine kinase''' (MAST) belongs to a family of proteins which contain a serine/threonine kinase domain and a PDZ domain. | '''Microtubule_associated serine/threonine kinase''' (MAST) belongs to a family of proteins which contain a serine/threonine kinase domain and a PDZ domain. | ||
| - | '''MAST1''' associates with the cytoskeleton and can bind through its PDZ domain both β-2-synthrophin and neuronal nitric oxide synthase. '''MAST2''' regulates | + | |
| - | lipopolysaccharide-induced IL-12 synthesis. | + | *'''MAST1''' associates with the cytoskeleton and can bind through its PDZ domain both β-2-synthrophin and neuronal nitric oxide synthase. |
| + | *'''MAST2''' regulates lipopolysaccharide-induced IL-12 synthesis. | ||
| + | *'''MAST L''' supports mitosis by phosphorylating PP2A/B55<ref>PMID:36354735</ref> | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | * | + | *Microtubule-associated serine/threonine kinase 1 |
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**[[3ps4]] – hMAST1 PDZ domain 965-1057 – human <br /> | **[[3ps4]] – hMAST1 PDZ domain 965-1057 – human <br /> | ||
**[[2m9x]] – hMAST1 residues 187-287 – NMR <br /> | **[[2m9x]] – hMAST1 residues 187-287 – NMR <br /> | ||
Current revision
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3D Structures of microtubule-associated serine/threonine kinase
Updated on 11-July-2024
References
- ↑ Sanz-Castillo B, Hurtado B, Vara-Ciruelos D, El Bakkali A, Hermida D, Salvador-Barbero B, Martínez-Alonso D, González-Martínez J, Santiveri C, Campos-Olivas R, Ximénez-Embún P, Muñoz J, Álvarez-Fernández M, Malumbres M. The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner. EMBO J. 2023 Jan 16;42(2):e110833. PMID:36354735 doi:10.15252/embj.2022110833
