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8jpb
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 1== | |
| - | + | <StructureSection load='8jpb' size='340' side='right'caption='[[8jpb]], [[Resolution|resolution]] 3.07Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8jpb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JPB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.07Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SRW:2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol'>SRW</scene>, <scene name='pdbligand=STU:STAUROSPORINE'>STU</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jpb OCA], [https://pdbe.org/8jpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jpb RCSB], [https://www.ebi.ac.uk/pdbsum/8jpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jpb ProSAT]</span></td></tr> |
| - | [[Category: Duan | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Liu | + | [https://www.uniprot.org/uniprot/ARBK1_BOVIN ARBK1_BOVIN] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity). |
| - | [[Category: Yuan | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Bos taurus]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Duan J]] | ||
| + | [[Category: Ji Y]] | ||
| + | [[Category: Liu H]] | ||
| + | [[Category: Xu HE]] | ||
| + | [[Category: Yuan Q]] | ||
| + | [[Category: Zhao F]] | ||
Current revision
cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 1
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Categories: Bos taurus | Homo sapiens | Large Structures | Synthetic construct | Duan J | Ji Y | Liu H | Xu HE | Yuan Q | Zhao F
