8p7w

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'''Unreleased structure'''
 
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The entry 8p7w is ON HOLD until Paper Publication
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==Structure of 5D3-Fab and nanobody(Nb8)-bound ABCG2==
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<StructureSection load='8p7w' size='340' side='right'caption='[[8p7w]], [[Resolution|resolution]] 3.04&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8p7w]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P7W FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.04&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p7w OCA], [https://pdbe.org/8p7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p7w RCSB], [https://www.ebi.ac.uk/pdbsum/8p7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p7w ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ABCG2_HUMAN ABCG2_HUMAN] High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.<ref>PMID:12958161</ref> <ref>PMID:20705604</ref> <ref>PMID:22132962</ref> <ref>PMID:23189181</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Lama glama]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Irobalieva RN]]
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[[Category: Jackson SM]]
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[[Category: Locher KP]]
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[[Category: Manolaridis I]]
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[[Category: Ni D]]
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[[Category: Pardon E]]
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[[Category: Stahlberg H]]
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[[Category: Steyaert J]]

Current revision

Structure of 5D3-Fab and nanobody(Nb8)-bound ABCG2

PDB ID 8p7w

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