1lg7

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[[Image:1lg7.jpg|left|200px]]
 
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==Crystal structure of Vesicular Stomatitis Virus Matrix Protein==
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The line below this paragraph, containing "STRUCTURE_1lg7", creates the "Structure Box" on the page.
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<StructureSection load='1lg7' size='340' side='right'caption='[[1lg7]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lg7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vesicular_stomatitis_virus Vesicular stomatitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LG7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
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{{STRUCTURE_1lg7| PDB=1lg7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lg7 OCA], [https://pdbe.org/1lg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lg7 RCSB], [https://www.ebi.ac.uk/pdbsum/1lg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lg7 ProSAT]</span></td></tr>
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</table>
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'''Crystal structure of Vesicular Stomatitis Virus Matrix Protein'''
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== Function ==
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[https://www.uniprot.org/uniprot/MATRX_VSIVC MATRX_VSIVC] Plays a major role in assembly and budding of virion. Condensates the ribonucleocapsid core during virus assembly. Shut off cellular transcription by inhibiting mRNA nuclear export through direct interaction with host RAE1-NUP98 complex. This shutoff presumably inhibit interferon signaling and thus establishment of antiviral state in virus infected cells. Induces cell-rounding, cytoskeleton disorganization and apoptosis in infected cell (By similarity).
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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The vesicular stomatitis virus (VSV) matrix protein (M) interacts with cellular membranes, self-associates and plays a major role in virus assembly and budding. We present the crystallographic structure, determined at 1.96 A resolution, of a soluble thermolysin resistant core of VSV M. The fold is a new fold shared by the other vesiculovirus matrix proteins. The structure accounts for the loss of stability of M temperature-sensitive mutants deficient in budding, and reveals a flexible loop protruding from the globular core that is important for self-assembly. Membrane floatation shows that, together with the M lysine-rich N-terminal peptide, a second domain of the protein is involved in membrane binding. Indeed, the structure reveals a hydrophobic surface located close to the hydrophobic loop and surrounded by conserved basic residues that may constitute this domain. Lastly, comparison of the negative-stranded virus matrix proteins with retrovirus Gag proteins suggests that the flexible link between their major membrane binding domain and the rest of the structure is a common feature shared by these proteins involved in budding and virus assembly.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lg/1lg7_consurf.spt"</scriptWhenChecked>
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1LG7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vesicular_stomatitis_virus Vesicular stomatitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LG7 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of vesicular stomatitis virus matrix protein., Gaudier M, Gaudin Y, Knossow M, EMBO J. 2002 Jun 17;21(12):2886-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12065402 12065402]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lg7 ConSurf].
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[[Category: Single protein]]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Vesicular stomatitis virus]]
[[Category: Vesicular stomatitis virus]]
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[[Category: Gaudier, M.]]
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[[Category: Gaudier M]]
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[[Category: Gaudin, Y.]]
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[[Category: Gaudin Y]]
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[[Category: Knossow, M.]]
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[[Category: Knossow M]]
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[[Category: Virus matrix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:53:29 2008''
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Current revision

Crystal structure of Vesicular Stomatitis Virus Matrix Protein

PDB ID 1lg7

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