8jw3
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The crystal structure of the viral terpene synthase from Orpheovirus IHUMI-LCC2== |
| + | <StructureSection load='8jw3' size='340' side='right'caption='[[8jw3]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8jw3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Orpheovirus_IHUMI-LCC2 Orpheovirus IHUMI-LCC2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JW3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jw3 OCA], [https://pdbe.org/8jw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jw3 RCSB], [https://www.ebi.ac.uk/pdbsum/8jw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jw3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A2I2L5I9_9PHYC A0A2I2L5I9_9PHYC] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Giant viruses are nonstandard viruses with large particles and genomes. While previous studies have shown that their genomes contain various sequences of interest, their genes related specifically to natural product biosynthesis remain unexplored. Here we analyze the function and structure of a terpene synthase encoded by the gene of a giant virus. The enzyme is phylogenetically separated from the terpene synthases of cellular organisms; however, heterologous gene expression revealed that it still functions as a terpene synthase and produces a cyclic terpene from a farnesyl diphosphate precursor. Crystallographic analysis revealed its protein structure, which is relatively compact but retains essential motifs of the terpene synthases. We thus suggest that like cellular organisms, giant viruses produce and utilize natural products for their ecological strategies. | ||
| - | + | Function and Structure of a Terpene Synthase Encoded in a Giant Virus Genome.,Jung Y, Mitsuhashi T, Sato S, Senda M, Senda T, Fujita M J Am Chem Soc. 2023 Dec 6;145(48):25966-25970. doi: 10.1021/jacs.3c10603. Epub , 2023 Nov 27. PMID:38010834<ref>PMID:38010834</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 8jw3" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Orpheovirus IHUMI-LCC2]] | ||
| + | [[Category: Fujita M]] | ||
| + | [[Category: Jung Y]] | ||
| + | [[Category: Mitsuhashi T]] | ||
| + | [[Category: Sato S]] | ||
| + | [[Category: Senda M]] | ||
| + | [[Category: Senda T]] | ||
Current revision
The crystal structure of the viral terpene synthase from Orpheovirus IHUMI-LCC2
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