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1lhp

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[[Image:1lhp.jpg|left|200px]]
 
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==Crystal Structure of Pyridoxal Kinase from Sheep Brain==
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The line below this paragraph, containing "STRUCTURE_1lhp", creates the "Structure Box" on the page.
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<StructureSection load='1lhp' size='340' side='right'caption='[[1lhp]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lhp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LHP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lhp OCA], [https://pdbe.org/1lhp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lhp RCSB], [https://www.ebi.ac.uk/pdbsum/1lhp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lhp ProSAT]</span></td></tr>
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{{STRUCTURE_1lhp| PDB=1lhp | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDXK_SHEEP PDXK_SHEEP] Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lh/1lhp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lhp ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of Pyridoxal Kinase from Sheep Brain'''
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==See Also==
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*[[Pyridoxal kinase|Pyridoxal kinase]]
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__TOC__
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==Overview==
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</StructureSection>
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The three-dimensional structures of brain pyridoxal kinase and its complex with the nucleotide ATP have been elucidated in the dimeric form at 2.1 and 2.6 A, respectively. Results have shown that pyridoxal kinase, as an enzyme obeying random sequential kinetics in catalysis, does not possess a lid shape structure common to all kinases in the ribokinase superfamily. This finding has been shown to be in line with the condition that pyridoxal kinase binds substrates with variable sizes of chemical groups at position 4 of vitamin B(6) and its derivatives. In addition, the enzyme contains a 12-residue peptide loop in the active site for the prevention of premature hydrolysis of ATP. Conserved amino acid residues Asp(118) and Tyr(127) in the peptide loop could be moved to a position covering the nucleotide after its binding so that its chance to hydrolyze in the aqueous environment of the active site was reduced. With respect to the evolutionary trend of kinase enzymes, the existence of this loop in pyridoxal kinase could be classified as an independent category in the ribokinase superfamily according to the structural feature found and mechanism followed in catalysis.
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[[Category: Large Structures]]
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==About this Structure==
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1LHP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LHP OCA].
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==Reference==
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Crystal structure of brain pyridoxal kinase, a novel member of the ribokinase superfamily., Li MH, Kwok F, Chang WR, Lau CK, Zhang JP, Lo SC, Jiang T, Liang DC, J Biol Chem. 2002 Nov 29;277(48):46385-90. Epub 2002 Sep 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12235162 12235162]
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[[Category: Ovis aries]]
[[Category: Ovis aries]]
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[[Category: Pyridoxal kinase]]
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[[Category: Jiang T]]
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[[Category: Single protein]]
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[[Category: Li MH]]
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[[Category: Jiang, T.]]
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[[Category: Liang DC]]
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[[Category: Li, M H.]]
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[[Category: Liang, D C.]]
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[[Category: Alpha-beta structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:55:57 2008''
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Current revision

Crystal Structure of Pyridoxal Kinase from Sheep Brain

PDB ID 1lhp

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