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1lht

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[[Image:1lht.jpg|left|200px]]
 
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==LOGGERHEAD SEA TURTLE MYOGLOBIN (CYANO-MET)==
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The line below this paragraph, containing "STRUCTURE_1lht", creates the "Structure Box" on the page.
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<StructureSection load='1lht' size='340' side='right'caption='[[1lht]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lht]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caretta_caretta Caretta caretta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LHT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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{{STRUCTURE_1lht| PDB=1lht | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lht OCA], [https://pdbe.org/1lht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lht RCSB], [https://www.ebi.ac.uk/pdbsum/1lht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lht ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MYG_CARCR MYG_CARCR] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lh/1lht_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lht ConSurf].
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<div style="clear:both"></div>
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'''LOGGERHEAD SEA TURTLE MYOGLOBIN (CYANO-MET)'''
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==See Also==
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*[[Myoglobin 3D structures|Myoglobin 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The X-ray crystal structures of the aquo-met and cyano-met derivatives of the loggerhead sea turtle (Caretta caretta) myoglobin have been determined at 2.0 A resolution (R = 0.182, and 0.178, respectively). The results here reported, representing the first reptile globin solved by X-ray crystallography, have been analyzed in parallel with data for related monomeric hemoproteins, and indicate a strong overall structural similarity between the loggerhead sea turtle and mammalian myoglobins, reflected by the 63% amino acid identity of their primary structures. The root-mean-square deviation between the entire polypeptide backbones of loggerhead sea turtle and sperm whale myoglobins, after structure superposition, is 0.83 A. Upon cyanide binding to the protein distal site, the iron-bound water molecule present in the aquo-met form is displaced by the incoming ligand. Cyanide is oriented towards the inner part of the heme distal site forming a Fe-C-N angle of 133 degrees.
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==About this Structure==
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1LHT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caretta_caretta Caretta caretta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LHT OCA].
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==Reference==
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Reptile heme protein structure: X-ray crystallographic study of the aquo-met and cyano-met derivatives of the loggerhead sea turtle (Caretta caretta) myoglobin at 2.0 A resolution., Nardini M, Tarricone C, Rizzi M, Lania A, Desideri A, De Sanctis G, Coletta M, Petruzzelli R, Ascenzi P, Coda A, et al., J Mol Biol. 1995 Mar 31;247(3):459-65. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7714901 7714901]
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[[Category: Caretta caretta]]
[[Category: Caretta caretta]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ascenzi, P.]]
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[[Category: Ascenzi P]]
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[[Category: Bolognesi, M.]]
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[[Category: Bolognesi M]]
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[[Category: Coda, A.]]
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[[Category: Coda A]]
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[[Category: Coletta, M.]]
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[[Category: Coletta M]]
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[[Category: Desideri, A.]]
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[[Category: De Sanctis G]]
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[[Category: Lania, A.]]
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[[Category: Desideri A]]
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[[Category: Nardini, M.]]
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[[Category: Lania A]]
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[[Category: Petruzzelli, R.]]
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[[Category: Nardini M]]
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[[Category: Sanctis, G De.]]
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[[Category: Petruzzelli R]]
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[[Category: Tarricone, C.]]
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[[Category: Tarricone C]]
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[[Category: Oxygen storage]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:56:07 2008''
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Current revision

LOGGERHEAD SEA TURTLE MYOGLOBIN (CYANO-MET)

PDB ID 1lht

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