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8t07

From Proteopedia

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Current revision (07:02, 27 September 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8t07 is ON HOLD until Paper Publication
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==Structure of mouse Myomaker mutant-Y118A bound to Fab18G7==
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<StructureSection load='8t07' size='340' side='right'caption='[[8t07]], [[Resolution|resolution]] 3.38&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8t07]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8T07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8T07 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.38&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8t07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8t07 OCA], [https://pdbe.org/8t07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8t07 RCSB], [https://www.ebi.ac.uk/pdbsum/8t07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8t07 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MYMK_MOUSE MYMK_MOUSE] Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers (PubMed:23868259, PubMed:28386024, PubMed:28681861, PubMed:30197239). Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of MYMX (PubMed:30197239). Acts independently of MYMX (PubMed:30197239). Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers (PubMed:25085416). Also involved in skeletal muscle hypertrophy, probably by mediating the fusion of satellite cells with myofibers (PubMed:28186492).<ref>PMID:23868259</ref> <ref>PMID:25085416</ref> <ref>PMID:28186492</ref> <ref>PMID:28386024</ref> <ref>PMID:28681861</ref> <ref>PMID:30197239</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Li X]]
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[[Category: Long T]]

Current revision

Structure of mouse Myomaker mutant-Y118A bound to Fab18G7

PDB ID 8t07

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OCA

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