8pr2
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Cytoplasmic dynein-1 heavy chain bound to JIP3-LZI== |
| - | + | <StructureSection load='8pr2' size='340' side='right'caption='[[8pr2]], [[Resolution|resolution]] 3.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8pr2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PR2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pr2 OCA], [https://pdbe.org/8pr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pr2 RCSB], [https://www.ebi.ac.uk/pdbsum/8pr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pr2 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/DYHC1_HUMAN DYHC1_HUMAN] Autosomal dominant childhood-onset proximal spinal muscular atrophy without contractures;Autosomal dominant non-syndromic intellectual disability;Autosomal dominant Charcot-Marie-Tooth disease type 2O. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DYHC1_HUMAN DYHC1_HUMAN] Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074).<ref>PMID:27462074</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Carter AP]] | ||
| + | [[Category: Gassmann R]] | ||
| + | [[Category: Lau CK]] | ||
| + | [[Category: Manigrasso G]] | ||
| + | [[Category: Singh K]] | ||
Current revision
Cytoplasmic dynein-1 heavy chain bound to JIP3-LZI
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